this paper introduces a novel methodology for the segmentation of brain ms lesions in mri volumes using a new clustering algorithm named scpfcm.  scpfcm uses membership, typicality and spatial information to cluster each voxel. the proposed method relies on an initial segmentation of ms lesions in t1-w and t2-w images by applying scpfcm algorithm, and the t1 image is then used as a mask and is ...

Demyelinating lesions of fiber bundles in and adjacent to the hypothalamus (i.e. the fornix. anterior commissure, internal capsule, and optic system) may be the basis for autonomic and endocrine alterations in multiple sclerosis (MS) patients. Therefore we investigated the presence and immunological activity of lesions in hypothalamic fiber bundles of 17 MS patients and 14 controls. In the MS g...

We reviewed and compared the neuropathology of multiple sclerosis (MS), neuromyelitis optica (NMO), neuromyelitis optica spectrum disorders (NMOSD) and acute disseminated encephalomyelitis (ADEM) in Japan. Demyelinating lesions of MS are well circumscribed as compared with the lesions of NMO and NMOSD, which reveal variable, irregularly shaped and ill-defined borders that extend longitudinally ...

BACKGROUND Brain stem lesions are common in patients with acute disseminated encephalomyelitis (ADEM), neuromyelitis optica (NMO), and multiple sclerosis (MS). OBJECTIVES To investigate comparative brain stem lesions on magnetic resonance imaging (MRI) among adult patients with ADEM, NMO, and MS. METHODS Sixty-five adult patients with ADEM (n = 17), NMO (n = 23), and MS (n = 25) who had bra...

background: multiple sclerosis (ms) is a degenerative disease of central nervous system. ms patients have some dead tissues in their brains called ms lesions. mri is an imaging technique sensitive to soft tissues such as brain that shows ms lesions as hyper-intense or hypo-intense signals. since manual segmentation of these lesions is a laborious and time consuming task, automatic segmentation ...

The Quality Standards Subcommittee of the American Academy of Neurology (AAN) is charged with developing practice parameters for neurologists for diagnostic procedures, treatment modalities, and clinical disorders. The selection of topics for which practice parameters are used is based on prevalence, frequency of use, economic impact, membership involvement, controversy, urgency, external const...

Mitochondrial dysfunction has been implicated in the development and progression of multiple sclerosis (MS) lesions. Mitochondrial alterations might occur as a response to demyelination and inflammation, since demyelination leads to an increased energy demand in axons and could thereby affect the number, distribution and activity of mitochondria. We have studied the expression of mitochondrial ...

We have examined the localization of inducible nitric oxide synthase (iNOS) and nitrotyrosine (the product of nitration of tyrosine by peroxynitrite, a highly reactive derivative of nitric oxide [NO]) in demyelinating lesions from (i) two young adult patients with acute multiple sclerosis (MS), (ii) a child with MS (consistent with diffuse sclerosis), and (iii) five adult patients with chronic ...