نتایج جستجو برای: mrs1706

تعداد نتایج: 13  

Journal: :Molecular pharmacology 2005
Avani Desai Cassandre Victor-Vega Swathi Gadangi M Carmen Montesinos Charles C Chu Bruce N Cronstein

Topical adenosine A2A receptor agonists promote wound healing by, among other effects, increasing microvessel formation. Results of representational display analysis of human umbilical vein endothelial cells suggested that A2A receptor occupancy modulates expression of the antiangiogenic matrix protein thrombospondin 1 (TSP1). We therefore determined whether A2A receptor occupation stimulates a...

Journal: :The Journal of pharmacology and experimental therapeutics 2006
Miguel Faria Teresa Magalhães-Cardoso José-Maria Lafuente-de-Carvalho Paulo Correia-de-Sá

Although adenosine has been implicated in penile erection in human males, the receptor subtype responsible for adenosine regulation of human corpus cavernosum (HCC) smooth muscle tone is still a matter of debate. Using selective adenosine agonists and antagonists, we aimed at characterizing the adenosine receptors mediating relaxation of precontracted (with 1 microM phenylephrine) HCC strips. H...

Journal: :Journal of immunology 2008
Sergey Ryzhov Rinat Zaynagetdinov Anna E Goldstein Sergey V Novitskiy Mikhail M Dikov Michael R Blackburn Italo Biaggioni Igor Feoktistov

Pharmacological studies suggest that A(2B) adenosine receptors mediate proinflammatory effects of adenosine in human mast cells in part by up-regulating production of Th2 cytokines and angiogenic factors. This concept has been recently challenged by the finding that mast cells cultured from bone marrow-derived mast cells (BMMCs) of A(2B) knockout mice display an enhanced degranulation in respon...

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