BACKGROUND/AIM Kinesin family member 1B (KIF1B) gene resides in the chromosomal region 1p36.22 and has been reported to have frequent deletions in a variety of human cancers. A recent genome wide association study (GWAS) study conducted on a Chinese population has reported the involvement of a KIF1B genetic variant in Hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). This study ai...

BACKGROUND Frequent deletions of the kinesin-like protein gene 1B (KIF1B) have been reported in neural tumors. Recently, a genome-wide association study revealed an association between polymorphisms in the KIF1B gene and the risk of hepatocellular carcinoma (HCC), and several case-control studies have further investigated this relationship. However, these studies have yielded controversial resu...

BACKGROUND/AIMS The association between the kinesin family member 1B (KIF1B) gene polymorphism and the risk of hepatitis B virus-related hepatocellular carcinoma (HCC) has been investigated in many peer-reviewed studies. However, scholars have failed to replicate these results in validation tests. The purpose of the present study was to explore whether the KIF1B rs17401966 polymorphism was asso...

KIF1Bは哺乳類のキネシンスーパーファミリーの一つ である.KIF1Bとアミノ酸配列上相同性の高い KIF1サブ ファミリーには KIF1A,KIF1B,KIF1Cが属し,線虫ホモ ログは UNC104である.KIF1サブファミリーは,一般的 に二量体である他のキネシンとは異なり,微小管に結合し ていない状態では単量体として存在すると考えられてい る.この興味深い特徴のため,微小管上を移動する際の メカニズムに関して,単量体あるいは二量体として機能す るかを含めて多くの研究がなされている. KIF1Bは1150アミノ酸,130kDaのタンパク質として 報告された(図1A,KIF1Bα).その後の研究により, 1770アミノ酸,200kDaのアイソフォームの存在が発見さ れた(KIF1Bβ).両者はアミノ末端側660アミノ酸につ いて全く同一であり,選択的スプライシングによって生じ ...

Early molecular events related to cytoskeleton are poorly described in Amyotrophic Lateral Sclerosis (ALS), especially in the Schwann cell (SC), which offers strong trophic support to motor neurons. Database for Annotation, Visualization and Integrated Discovery (DAVID) tool identified cytoskeleton-related genes by employing the Cellular Component Ontology (CCO) in a large gene profiling of lum...

BACKGROUND A recent genome-wide association study has identified a new susceptibility locus, kinesin family member 1B gene (KIF1B), strongly associated with progression from chronic hepatitis B (CHB) to hepatitis B virus-related hepatocellular carcinoma (HCC) in Chinese population, this study was carried out to explore the role of the genetic variants in KIF1B in the development of chronic hepa...

The size of the nondominated set of a vector set is greatly dependent on the size of the original vector set N and the dimension of the vector M . Theoretical analysis shows that when M = O(log N) the original set has big nondominated set which may be the original set itself, and in the case M = O(log N), a classical algorithm (KLP) for finding nondominated set has complexity of KLP higher than...

Oligodendrocytes in the central nervous system produce myelin, a lipid-rich, multilamellar sheath that surrounds axons and promotes the rapid propagation of action potentials. A critical component of myelin is myelin basic protein (MBP), expression of which requires anterograde mRNA transport followed by local translation at the developing myelin sheath. Although the anterograde motor kinesin K...