Mean platelet volume (MPV) and platelet distribution width (PDW) are morphometric indices of size distribution and variability of platelet. We aimed to explore the associations between MPV or PDW and thyroid function in a large Chinese cohort.This was a cross-sectional study with a recruitment of 13,622 self-reported healthy Chinese (8424 males, 5198 females). Clinical data of the participants ...

We retrospectively analyzed the association between mean platelet volume (MPV) and prognosis in 62 newly diagnosed multiple myeloma (MM) patients. The associations between MPV and clinical characteristics were assessed. The log-rank test and the Cox proportional hazards model were used to evaluate the effect of MPV on survival. A MPV value of 8.50 fl was considered to be the optimal cut-off val...

BACKGROUND Systemic inflammation is related to disease progression in asthma. Activated platelets play a critical role in atherogenesis, inflammation, and atherothrombosis. The mean platelet volume (MPV) is an early marker of platelet activation. OBJECTIVES The aim of this study is to clarify the relevance of MPV levels in patients with stable and exacerbated asthma. METHODS We investigated...

OBJECTIVE Mean platelet volume (MPV) is a determinant of inflammation. The aim of the present study was to investigate the MPV levels in children with rotavirus gastroenteritis and to evaluate the possible relationship between MPV and severity of gastroenteritis. METHODS Children diagnosed with acute rotavirus gastroenteritis and healthy controls were enrolled in this study. Patients were cla...

Mean platelet volume (MPV) is an indicator of platelet activation that is elevated in patients with coronary artery ectasia (CAE). We aimed to research relationship between MPV and the severity of coronary ectasia. The reports of 6,377 patients who underwent elective coronary angiography screening between January 2011 and January 2015 were reviewed. After exclusion, 117 patients with isolated C...

Polymyositis (PM) is an autoimmune disease characterized by chronic inflammation in skeletal muscle. Mean platelet volume (MPV), a marker in the assessment of systemic inflammation, is easily measured by automatic blood count equipment. However, to our knowledge, there are no data in the literature with respect to MPV levels in PM patients. Therefore, in this study we aimed to investigate MPV l...

The aim of the present study was to evaluate the predictive efficiency of mean platelet volume (MPV) and platelet size deviation width (PDW) for bone marrow failure (BMF) in thrombocytopenic patients. Platelet count, MPV and PDW data were retrieved from the records of 574 unselected thrombocytopenic patients from between March 2010 and March 2011, of which 182 patients with a platelet count <20...

OBJECTIVE The interindividual variation in platelet α(2)β(1) exceeds a 2-fold variance in platelet α(IIb)β(3) level. Our objective was to parse the contribution of mean platelet volume (MPV) and integrin gene alleles to this variation in large cohorts of patients with acute coronary syndrome (ACS) and normal subjects. METHODS AND RESULTS Platelet α(IIb)β(3) and α(2)β(1) levels were measured b...

BACKGROUND Prediabetes is an independent risk factor for cardiovascular diseases. Mean platelet volume (MPV) can reflect platelet activity, and high MPV is associated with thrombogenic activation and an increased risk of cardiovascular disease. In diabetic patients, MPV is higher when compared with normal subjects. However, the relationship between MPV and prediabetes is poorly understood. The ...

BACKGROUND AND OBJECTIVES The relationship of the mean platelet volume (MPV) and C-reactive protein (CRP) values with mortality in patients with ischemic stroke is not clear. Besides, the correlation between CRP and MPV in patients with ischemic stroke has not been adequately studied yet. In the present study, our aim is to investigate the interrelationship of the CRP and MPV parameters togethe...