Mouse embryonic fibroblasts that are deficient in the two mannose 6-phosphate receptors (MPRs) MPR 46 and MPR 300 missort the majority (> or = 85%) of soluble lysosomal proteins into the medium. Human MPR 46 and MPR 300 were expressed in these cells to test whether overexpression of a single type of MPR can restore transport of lysosomal proteins to lysosomes. Only a partial correction of the m...

The membrane proximal region (MPR, residues 649-683) and transmembrane domain (TMD, residues 684-705) of the gp41 subunit of HIV-1's envelope protein are highly conserved and are important in viral mucosal transmission, virus attachment and membrane fusion with target cells. Several structures of the trimeric membrane proximal external region (residues 662-683) of MPR have been reported at the ...

BACKGROUND Classically, progesterone has been thought to act only through the well-known genomic pathway involving hormone binding to nuclear receptors and subsequent modulation of gene expression. However, there is increasing evidence for rapid, non-genomic effects of progesterone in a variety of mammalian tissues and it is possible that a membrane PR (mPR) is causing these events. We recently...

Development of multi-detector row computed tomography (MDCT) has enabled three-dimensions (3D) scanning with minute voxels. Minute voxels improve spatial resolution of CT images. At the same time, however, they increase image noise. Multi-planar reconstruction (MPR) is one of effective 3D-image processing techniques. The conventional MPR technique can adjust slice thickness of MPR images. When ...

Medium access control (MAC) protocols making use of multipacket reception (MPR) capability achieve better throughput than conventional MAC protocols. When a wireless network operates with MPR capable nodes and non-MPR nodes, the MAC protocols must not only utilise the MPR capability to maximise throughput, but must also enable the co-existence with these two types of nodes. We propose a new MPR...

This phase 3 trial (Eastern Cooperative Oncology Group [ECOG] E1A06) compared melphalan, prednisone, and thalidomide (MPT-T) with melphalan, prednisone, and lenalidomide (mPR-R) in patients with untreated multiple myeloma (MM). A noninferiority design was used, and inferiority was defined as a progression-free survival (PFS) hazard ratio (HR) of MPT-T/mPR-R ≤0.82. A total of 306 patients enroll...

Accurate pre-operative localization and removal of disc material are important for minimizing morbidity in dogs with thoracolumbar disc extrusions. Computed tomography (CT) is an established technique for localizing disc extrusions in dogs, however the effect of multi-planar reformatting (MPR) on surgeon diagnostic performance has not been previously described. The purpose of this study was to ...

In this paper, the effects of multipacket reception (MPR) capability on the capacity of wireless networks with regular structures are analyzed. Under uniform traffic and minimum connectivity, the maximum stable packet generation rate for the MPR Manhattan networks is obtained. For a network of size N , it is shown that the capacity is K1/ √ N , and adding MPR affects the coefficient K1 of a non...

ODMRP protocol is an on-demand multicast routing protocol in mobile ad-hoc network. This paper presents the On-Demand Multicast Routing Protocol with Multipoint Relay(ODMRP-MPR) which bases on ODMRP. ODMRP-MPR inducts multipoint relay technique to reduce the control overhead, obtain high scalability and effectively solve the unidirectional link problem of wireless communication. At the same tim...

BACKGROUND Clinical trials evaluating the efficacy of dabigatran followed a very strict protocol, which included close monitoring and follow-up. Patients followed in this controlled environment had an average medication possession ratio (MPR) greater than 0.95. However, very few studies have evaluated patient adherence to dabigatran in a real-world setting. Other studies of chronic medications ...