نتایج جستجو برای: moxonidine

تعداد نتایج: 185  

Journal: :Cardiovascular research 2011
Jun-Feng Peng Zhao-Tang Wu Yang-Kai Wang Wen-Jun Yuan Tao Sun Xin Ni Ding-Feng Su Wei Wang Ming-Juan Xu Wei-Zhong Wang

AIMS The depressor action of the centrally antihypertensive drug moxonidine has been attributed to activation of I(1)-imidazoline receptor in the rostral ventrolateral medulla (RVLM). The objective of this study was to determine the role of the γ-aminobutyric acid (GABA) mechanisms in the RVLM in mediating the effect of moxonidine in anaesthetized normotensive rats. METHODS AND RESULTS The re...

Journal: :The Journal of pharmacology and experimental therapeutics 1999
C A Fairbanks G L Wilcox

alpha2-Adrenergic receptor (AR)-selective compounds produce antihypertensive and antinociceptive effects. Moxonidine alleviates hypertension in multiple species, including humans. This study demonstrates that intrathecally administered moxonidine produces antinociception in mice. Antinociception was detected via the (52.5 degrees C) tail-flick and Substance P (SP) nociceptive tests. Moxonidine ...

Journal: :Autonomic Neuroscience 2016
Thales B. Alves Leonardo T. Totola Ana C. Takakura Eduardo Colombari Thiago S. Moreira

The antihypertensive drugs moxonidine and clonidine are α2-adrenoceptor and imidazoline (I1) agonists. Previous results from our laboratory have shown that moxonidine can act in the commissural nucleus of the solitary tract (commNTS). In addition, some studies have shown that GABA or glutamate receptor blockade in the RVLM blunted the hypotension produced by these antihypertensive agents in spo...

Journal: :Cardiovascular research 2009
Jie Peng Yang-Kai Wang Li-Gang Wang Wen-Jun Yuan Ding-Feng Su Xin Ni Xiao-Ming Deng Wei-Zhong Wang

AIMS The central antihypertensive drug moxonidine lowers blood pressure (BP) through stimulating an imidazoline receptor within the rostral ventrolateral medulla (RVLM). Nitric oxide (NO) generated by the inducible NO synthase (iNOS) in the RVLM has been suggested to be involved in tonic sympathetic inhibition. The aim of this study was to determine the role of NO generated by iNOS in mediating...

Journal: :The Journal of pharmacology and experimental therapeutics 2002
Ulrich Schäfer Christof Burgdorf Astrid Engelhardt Thomas Kurz Gert Richardt

Numerous studies support the concept that centrally acting antihypertensive drugs, such as imidazolines, mediate sympathoinhibition not only via activation of central nervous alpha2-adrenoceptors (alpha2-AR) but also via imidazoline-1 receptors (I1-R). An additional presynaptic involvement in sympathetic neurotransmission of imidazolines, via I1-R independent of alpha2-AR, is still controversia...

Journal: :Neuro-Signals 2004
Antonio R Granata

We used an intracellular recording technique in vitro to investigate the effects of moxonidine on neurons in the rostral ventrolateral medulla (RVLM) with electrophysiological properties similar to premotor sympathetic neurons in vivo. These neurons were classified as firing regularly and irregularly, according to previous reports. Moxonidine is a sympathoinhibitory and antihypertensive agent t...

Journal: :British journal of pharmacology 1994
P Li S B Penner D D Smyth

1. I1 non-adrenoceptor, imidazoline receptor agonists, such as moxonidine, increase urine flow rate and sodium excretion following infusion into the renal artery. The functions of these agonists in genetic and acquired models of hypertension have not been determined. 2. We therefore studied the renal effects of two known non-adrenoceptor, imidazoline receptor agonists, rilmenidine and moxonidin...

Journal: :Circulation 2014
Georgios Giannopoulos Charalampos Kossyvakis Michael Efremidis Apostolos Katsivas Vasiliki Panagopoulou Konstantinos Doudoumis Konstantinos Raisakis Konstantinos Letsas Ilias Rentoukas Vlasios Pyrgakis Antonis S Manolis Dimitrios Tousoulis Christodoulos Stefanadis Spyridon Deftereos

BACKGROUND The autonomic system is an important determinant of atrial arrhythmogenesis. Current evidence indicates that a combined sympathovagal drive is most commonly responsible for eliciting atrial fibrillation (AF) episodes. The purpose of this study was to test whether moxonidine, a centrally acting sympathoinhibitory agent, can lead to a reduction in postablation AF recurrence. METHODS ...

Journal: :Clinical science 2006
Reza Mobini Michael Fu Per-Anders Jansson Claes-Håkan Bergh Margareta Scharin Täng Finn Waagstein Bert Andersson

Although beta-adrenergic blockade is beneficial in heart failure, inhibition of central sympathetic outflow using moxonidine has been associated with increased mortality. In the present study, we studied the acute effects of the imidazoline-receptor agonist moxonidine on haemodynamics, NA (noradrenaline) kinetics and myocardial metabolism. Fifteen patients with CHF (chronic heart failure) were ...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2006
Mitsuo Tanabe Yurika Kino Motoko Honda Hideki Ono

Imidazoline receptors are expressed widely in the CNS. In the present study, whole-cell patch-clamp recordings were made from medium spiny neurons in dorsal striatum slices from the rat brain, and the roles of I1-imidazoline receptors in the modulation of synaptic transmission were studied. Moxonidine, an I1-imidazoline receptor agonist, decreased the GABAA receptor-mediated IPSCs in a concentr...

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