The inhibitory effect of agmatine on electrically induced contractions was studied in vas deferens of Adra 2a transgenic mice lacking -adrenoceptors. Agmatine and clonidine caused a concentration-dependent inhibition of twitches. However, while agmatine showed a similar pIC value in control and transgenic mice, the pIC value for clonidine was about 30-fold lower in knockout mice. In both strain...

The inhibitory effect of agmatine on electrically induced contractions was studied in vas deferens of Adra 2a transgenic mice lacking alpha(2A)-adrenoceptors. Agmatine and clonidine caused a concentration-dependent inhibition of twitches. However, while agmatine showed a similar pIC(50) value in control and transgenic mice, the pIC(50) value for clonidine was about 30-fold lower in knockout mic...

We evaluated a biodegradable graft for reconstruction of rat vasa deferentia with long obstructed or missing segments. A total of 47 Sprague-Dawley rats underwent bilateral vasectomy and were divided into groups according to length of the vas deferens affected (0.5, 1, 1.5 cm). After 8 weeks, poly-(D,L-lactide) (PDLA) grafts were used to reconnect the vas deferens. Grafts and adjoining vasa def...

Insertion of a copper wire into the vas deferens of male rats released 4 micrograms of copper in themid portion of the vas deferens in two days time. In urethral and epidymal segments of the vas deferens copper released was less than one microgram. The present study demonstrates that the in vivo effects of 4 microgram of copper in 2 days time in the vas deferens are enough to induce antifertili...

Among rat peripheral tissues examined, Ins(1,4,5)P(3) receptor binding is highest in the vas deferens, with levels about 25% of those of the cerebellum. We have purified the InsP(3) receptor binding protein from rat vas deferens membranes 600-fold. The purified protein displays a single 260 kDa band on SDS/PAGE, and the native protein has an apparent molecular mass of 1000 kDa, the same as in c...

The ductus deferens of the mouse contains a major protein with a molecular weight of 34.5 kd called mouse vas deferens protein (MVDP). Immunofluorescence histochemistry and immunoblotting with monoclonal antibodies have been used to investigate the localization, tissue, and species distribution, androgen-regulation, and developmental expression of this protein. Consistent positive immunoreactio...

Repair of congenital groin hernia/hydrocele and orchidopexy for the undescended testis are the most common surgical procedure performed by pediatric surgeons. Up to 1% of all men have been reported to have a congenital unilateral absence of the vas deferens (CUAVD).1 Previous studies have suggested that ipsilateral renal anomalies are present in up to 91% of men with a congenital unilateral abs...