Purpose To explore the neurotrophic factor expression in corneal epithelium and evaluate their effects on the trigeminal ganglion (TG) neurite outgrowth and corneal nerve regeneration in mice. Methods The expression of neurotrophic factors was compared among the intact, regenerating, and regenerated mouse corneal epithelium. Mouse primary TG neurons were treated with the conditioned medium of...

background: it has been known that brain-derived neurotrophic factor (bdnf) is involved in neural survival and long term memory (ltm). here we hypothesized that bdnf as a potent neurotrophic factor might modulate amnestic effect induced by morphine. objectives: the aim of this study was to examine whether infusion of exogenous bdnf in the ca1 regions of the dorsal hippocampi could ameliorate me...

The physiology of brain-derived neurotrophic factor signaling in enkephalinergic striatopallidal neurons is poorly understood. Changes in cortical Bdnf expression levels, and/or impairment in brain-derived neurotrophic factor anterograde transport induced by mutant huntingtin (mHdh) are believed to cause striatopallidal neuron vulnerability in early-stage Huntington's disease. Although several ...

PURPOSE To determine whether subretinal Schwann cell transplantation can prolong the survival of photoreceptors in the rhodopsin knockout (rho(-/-)) mouse. METHODS Schwann cells were prepared from postnatal day (PN) 5 to 7 mouse pups and grafted subretinally into the eyes of PN35 rho(-/-) mice. RT-PCR was performed on similarly prepared cells to determine growth factor production in vitro. Ey...

Proper development of the nervous system requires a temporally and spatially orchestrated set of events including differentiation, synapse formation and neurotransmission. Nerve growth factor (NGF) acting through the TrkA neurotrophin receptor (also known as NTRK1) regulates many of these events. However, the molecular mechanisms responsible for NGF-regulated secretion are not completely unders...

background exposure to morphine decreases neurogenesis in the hippocampus. recent studies have shown that voluntary running decreases the severity of anxiety behaviors and cognitive deficits, and increased synaptic plasticity in morphine-dependent rats. objectives this study aimed to investigate whether the morphine dependence-induced attenuation of hippocampal neuron number in rats would be re...

post-traumatic stress disorder (ptsd) is a syndrome causing from a severe traumatic happening that leads to threatened death or injury. ptsd is associated with changes in limbic, hippocampal, and prefrontal cortical region function due to changes in synaptogenesis, dendritic modifying, and neurogenesis. changes in neuron in ptsd patients result from pathophysiological disturbances in inflammato...

many investigators are interested in finding the new cultural systems that can support the in vitro development of pre-implantation embryos better. previous studies suggested that growth factors such as epidermal growth factor (egf) are important in pre-implantation embryo development and implantation process. on the other hand, it is very important to support post thaw development of frozen em...

Purpose: To determine the inhibitory effect of curcumin on expression brain-derived neurotrophic factor (BDNF) in hippocampus mice with sleep deprivation.
 Methods: Expressions BDNF and miRNA-206 were evaluated using quantitative real time-polymerase chain reaction (qRT-PCR) a sleep-deprived mouse model. Interaction was assessed by dual luciferase qPCR) assays. The also determined qRT-PCR....

Objective(s): We sought to explore whether neuregulin-1(NRG1) would have a protective effect on the auditory cortices of adult C57BL/6J mice.Materials and Methods: We used RTPCR and Western blot (WB) to detect the expression of NRG1 and ERBB4 (the receptor of NRG1) in the auditory cortices of C57BL/6J mice of different ages (6–8 weeks an...