the transcriptional factor oct4 regulates pluripotency of stem cells and has an important role during oocyte growth. whereas, its role has remained ambiguous in ovarian tissue during reproductive cycle. therefore, this study was aimed to investigate the expression patterns of oct4 in mouse ovaries during the normal estrous cycle. adult national medical research institute mice were classified as...

background: nicotine exposure causes impaired fertility and ovarian dysfunction. the aim of this study was to investigate the possible protective role of melatonin, which is known as an antioxidant agent on altered ovarian functions upon nicotine exposure. methods: a total of 32 female adult nmri mice were divided randomly into four groups (n=8). the control group received vehicle, while group ...

nicotine is one the chemical substance with high level of toxically. it crosses the placenta and accumulates in the developing organs of fetus. our previous investigations indicated that collagen type iv plays a key role in basement membrane of various embryonic organs. in this study we evaluated the effect of maternal nicotine exposure pre and postnatal period on collagen iv expression during ...

protein tyrosine phosphatases (ptpases) regulate the tyrosine phosphorylation of target proteins in volved in several biological activities including cell proliferation and transformation. protein tyrosine phosphatase e (ptpe) contains duplicated ptpase-like domains and a short extracellular region. us ing the fluorescence in situ hybridization method, the gene encoding ptpe (locus symbol ptpre...

many investigators are interested in finding the new cultural systems that can support the in vitro development of pre-implantation embryos better. previous studies suggested that growth factors such as epidermal growth factor (egf) are important in pre-implantation embryo development and implantation process. on the other hand, it is very important to support post thaw development of frozen em...

background: induction of ovulation in art is necessary for superovulation and the side effects of superovulatory drugs are debated. oxytocin as a natural hormone, have receptors and is synthesized by several reproductive organs. preovulatory presence of oxytocin receptor mrnas in granulosa cells indicating a role for oxytocin in follicular development. objective: the aim of the present study wa...

background: cytotoxic therapy can lead to prolonged azoospermia or even sterility. in the present study, we investigated the morphological changes of mouse testes after gamma-radiation. methods: after anaesthetizing of nmri mice, testes and their surrounding tissues were irradiated using a cobalt therapy machine. four experimental groups were irradiated with fractionated doses of: 1.5+8, 1.5+12...

background: all-trans retinol is a biological antioxidantscavenging the ros in the cell culture. objectives: this studywas conducted to investigate the effect of all-trans retinol infertilization and culture medium on mouse embryo's developmentalcompetence. methods: this study was designed into twoexperiments. in the first experiment, in vitro mature oocytes wereco-cultured with sperm in fertil...

background: this study aimed to design a new mouse and evaluate some of its functional parameters. the prototype of an ergonomic mouse was made according to design principles. methods: the study was conducted from 2011 to 2013 in the department of ergonomics in shiraz university of medical science. functional parameters including movement time (mt) and error rate of the new mouse were evaluated...