Background and Objective: Evaluation of degenerative changes of motoneurons and their related synapses can be useful in understanding the mechanisms of neurodegenerative diseases and their potential treatment. The present electron microscopic and immunohistochemical study investigates the axotomy-induced...

objective(s): ischemia/reperfusion (i/r) injury of spinal cord is leading to the paraplegia observed. in this study, we investigated the protective effect of the saffron extract on spinal cord i/r injury. materials and methods: thirty five male sprague-dawley rats were divided into 5 groups: intact, sham surgery, normal saline (ns), low dose saffron aqua extract, high dose saffron aqua extract....

Spinal circuits can generate locomotor output in the absence of sensory or descending input, but the principles of locomotor circuit organization remain unclear. We sought insight into these principles by considering the elaboration of locomotor circuits across evolution. The identity of limb-innervating motor neurons was reverted to a state resembling that of motor neurons that direct undulato...

introduction: nigrothalamocortical tract is one of the main outputs of the basal nuclei, but its role in motor disturbances is vauge, because there is little informations on its connection structure. some electrophysiological and pharmacological surveys report that none-dopaminergic outputs originate from reticular part of substantia nigra and end at thalamus. in this study the topographical co...

The motor neuron progenitor domain in the ventral spinal cord gives rise to multiple subtypes of motor neurons and glial cells. Here, we examine whether progenitors found in this domain are multipotent and which signals contribute to their cell-type-specific differentiation. Using an in vitro neural differentiation model, we demonstrate that motor neuron progenitor differentiation is iterativel...