Frontotemporal dementia and motor neuron disease share clinical, genetic and pathological characteristics. Motor neuron disease develops in a proportion of patients with frontotemporal dementia, but the incidence, severity and functional significance of motor system dysfunction in patients with frontotemporal dementia has not been determined. Neurophysiological biomarkers have been developed to...

BACKGROUND Corticobasal syndrome (CBS) is characterized by multifaceted motor system dysfunction and cognitive disturbance; distinctive clinical features include limb apraxia and visuospatial dysfunction. Transcranial magnetic stimulation (TMS) has been used to study motor system dysfunction in CBS, but the relationship of TMS parameters to clinical features has not been studied. The present st...

The potential usefulness of chromaffin cells as a source of neuroactive agents for transplantation in the CNS is based on several promising features, including the diversity of biologically active neurotransmitters, neuropeptides and trophic factors produced by the cells. The purpose of this study was to test the possibility that motor as well as sensory dysfunction is reduced by cultured chrom...

The potential usefulness of chromaffin cells as a source of neuroactive agents for transplantation in the CNS is based on several promising features, including the diversity of biologically active neurotransmitters, neuropeptides and trophic factors produced by the cells. The purpose of this study was to test the possibility that motor as well as sensory dysfunction is reduced by cultured chrom...

Introduction: Astrocyte dysfunction is the common pathology resulting in failure of astrocyte-neuron interaction in neurological diseases, including Parkinson’s Disease (PD). To date, only few experimental models of selective ablation of astrocytes are known. The aim of present study was to evaluate the effect of striatal injections of selective glial toxin L-aminoadipic acid (L-AA) on the loco...

Functional differentiation is found in the spinal cord. A unique set of neurological deficits follows a multi-focal injury. Clinically, sensory and motor disturbance present independently, often resulting in sensory and motor deficit dissociation. This study examined 103 spinal decompression illness (DCI) cases. The neurological deficit dissociation was classified as follows: 1) Cases with sens...