Neuropeptide FF (NPFF) modulates opiate actions. It has pro-nociceptive effects, primarily through the NPFF receptor 1 subtype, and anti-nociceptive effects, primarily through the NPFFR2 subtype. AC-263093 is a small l, organic, systemically active molecule that was previously shown to functionally activate NPFFR2, but not NPFFR1. It was hypothesized that AC-263093 would attenuate morphine tole...

AIM To investigate the effects of morphine dependence and withdrawal on the concentrations of neurosteroids in rat brain. METHODS A method of simultaneous quantification of neurosteroids by gas chromatography-mass spectrometry (GC-MS) had been established. RESULTS The chronic morphine administration (ip) resulted in a marked decrease in the brain concentrations of pregnenolone (PREG), proge...

In order to compare the venodilation effect of morphine in normal individuals (22) with that in patients (13) with heart failure morphine sulfate (0.1 mg/kg) was administered to 13 patients with mild pulmonary edema. After morphine congestive symptoms improved and venodilation was induced as determined by two independent techniques: venous pressure fell 10.2 mm Hg by the isolated hand technique...

objective: the present study was designed to investigate the analgesic effect of oral and i.p. administration of alcoholic viscum album (v.a) fruit extract as a rich source of alkaloid substances. materials and methods: experimented animals were divided into control and treatment groups. the treatment rats received different doses of the v.a fruit extract, which was prepared from alcoholic sma...

introduction: nowadays opioids are gaining acceptance for the management of moderate to severe and chronic pain. in addition, a number of studies have shown that plasma levels of β-endorphin (βep) in exercise trained are higher than sedentary rats. in our study we assume that exercise training can reduce pain after withdrawal syndrome in morphine-dependent rats. methods: male wistar rats (250±2...

conclusions intravenous paracetamol appears to provide better analgesia than intravenous morphine in acute limb trauma. further larger studies are required. objectives this study was conducted to compare intravenous paracetamol and intravenous morphine sulfate for acute pain reduction in patients with limb trauma. patients and methods in a randomized double-blinded clinical trial, all patients ...

Ingestion of placenta and amniotic fluid has been shown to enhance opioid-mediated analgesia in rats produced by morphine injection, footshock, vaginal/cervical stimulation, and during late pregnancy. The present study was designed to investigate the effects of amniotic fluid ingestion on the characteristics of morphine dependency and withdrawal. Tail-flick latencies in Long-Evans rats were det...

A recently completed study quantified the percent of fentanyl or morphine sulfate lost to uncoated polyvinylchloride (PVC) tubing or to one of two hollow fiber oxygenators within the extracorporeal life support (ECLS) circuit. The results demonstrated the majority of drug loss was due to adsorption by the PVC tubing. The purpose of this study was to determine if a tubing coating process affects...