نتایج جستجو برای: montelukast sodium
تعداد نتایج: 188621 فیلتر نتایج به سال:
A simple, accurate, economical and reproducible reverse phase high performance liquid chromatographic (RP-HPLC) method was developed and validated for the determination of montelukast sodium and fexofenadine hydrochloride in bulk and pharmaceutical formulations. The separation was achieved on a phenomenex C column (150 × 4.6 mm i.d, particle size of 5μ) using a mixture of 0.1M potassium dihydro...
A simple, accurate, rapid and precise isocratic reversed-phase high-performance liquid chromatographic method has been developed and validated for simultaneous determination of levocetirizine and montelukast sodium in tablets. The chromatographic separation was carried out on Atlantis C-18 analytical column (4.6×150 mm; 5μm) with a mixture of 10Mm acetonitrile:ammonium acetate (65:35 % v/v and ...
prostate cancer is a devastating disease for which current therapies are inadequate. various lines of evidences have suggested the 5-lipoxygenase (5-lox) pathway and the leukotriene receptor pathway are potential targets for prevention or treatment of prostate cancer. thus, search for new anti-cancer drugs targeting 5-lox and leukotriene is very essential and important. the objective of the pre...
A rapid and sensitive RP-HPLC method with UV detection (244 nm) for routine analysis of montelukast sodium and ebastine in a pharmaceutical formulation (Ebast-M) was developed. Chromatography was performed with mobile phase containing a mixture of methanol:acetonitrile:ammonium acetate (80:10:10, % v/v/v), pH of mobile phase was adjusted 5.5 using glacial acetic acid and flow rate was 1.2 ml/mi...
PURPOSE The purpose of this study was to evaluate the efficacy and safety of Montelukast sodium in the prevention of bronchopulmonarydysplasia (BPD). METHODS The Interventional study was designed as a multicenter, prospective, and randomized trial, with open labeled and parallel-experimental groups, 66 infants were enrolled and allocated to either the case group (n=30) or the control group (n...
OBJECTIVES The efficacy and safety of a single-dose of Montelukast sodium for treating virus-related infantile wheezing are investigated in this study. PATIENTS AND METHODS A prospective, open, randomized, controlled study was carried out on 595 cases of infants who exhibited wheezing after a respiratory syncytial virus infection. Treatment with Montelukast sodium was provided over the course...
In this study, a potentiometric titration method for the determination of montelukast sodium in pharmaceutical dosage forms was developed and validated. For this purpose, the potentiometric titration of the standard montelukast sodium was carried out using hydrochloric acid as titrant. The method was found to be highly accurate and precise, having a relative standard deviation of less than 1.0%...
INTRODUCTION One of the most common complaints in patients with end-stage renal disease (ESRD) is uremic pruritus. In the recent years, many drugs have been proposed for its treatment which have had paradoxical outcomes. We studied the antipruritus effect of montelukast sodium, a leukotriene receptor antagonist, in patients on hemodialysis. MATERIALS AND METHODS The study was conducted as ran...
INTRODUCTION Uremic pruritus is one of the most common disabling symptoms in patients with end-stage renal disease. We aimed to study the effect of montelukast sodium for the treatment of uremic pruritus lasting more than 3 months in patients undergoing hemodialysis and compare it with placebo. METHODS AND MATERIALS Eighty patients undergoing hemodialysis at 3 centers in Shiraz, Iran, were re...
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