background: the aim of this study was to evaluate the effectiveness of monotherapy with interferon alpha-2b and combination therapy with interferon alpha-2b plus ribavirin on chronic hepatitis c infection in thalassaemic patients. methods: in parallel group randomized, double blind, controlled trial, 32 thalassaemic patients with chronic hepatitis c infection completed the study. in a random fa...

PURPOSE Perampanel is approved for adjunctive treatment of focal seizures, with or without secondarily generalised seizures, and for primary generalised tonic-clonic seizures in people with epilepsy aged ≥12 years. Perampanel was recently approved for monotherapy use for partial seizures in the United States. This study provides insight into the feasibility of perampanel monotherapy in real-wor...

OBJECTIVE We undertook this phase III study to evaluate baricitinib, an orally administered JAK-1/JAK-2 inhibitor, as monotherapy or combined with methotrexate (MTX) compared to MTX monotherapy in patients with active rheumatoid arthritis (RA) who had received no or minimal conventional synthetic disease-modifying antirheumatic drugs (DMARDs) and who were naive to biologic DMARDs. METHODS A t...

Interest in the role of insulin sensitizing drugs (ISDs) as a means of reducing compensatory hyperinsulinemia in the hope of improving metabolic and reproductive functions in women with PCOS has grown measurably over the past decade. Metformin is believed to lower fasting serum insulin levels in insulin-resistance. For the management of ovulatory infertility in the nonobese PCOS population (BMI...

background recently, several reports issued clevudine induced myopathy in the long term use. objectives the aim of this study was to investigate antiviral effects and adverse events of clevudine monotherapy in patients with chronic hepatitis b (chb). patients and methods the subjects were 110 treatment-naïve chb patients. they were treated with 30 mg clevudine/day for more than six months. viro...

BACKGROUND In patients who remain virologically suppressed in plasma with triple-drug ART a switch to protease inhibitor monotherapy maintains high rates of suppression; however it is unknown if protease inhibitor monotherapy is associated to a higher rate of neurocognitive impairment. METHODS In this observational, cross-sectional study we included patients with plasma virological suppressio...

BACKGROUND During the past 25 years recommendations for treating hypertension have evolved from a stepped-care approach to monotherapy or sequential monotherapy as experience has been gained and new antihypertensive agents have been introduced. In an effort to develop a disease management strategy for hypertension, we investigated the prescribing patterns of initial medication therapy for newly...