نتایج جستجو برای: monophosphoryl lipid a
تعداد نتایج: 13481193 فیلتر نتایج به سال:
Lipid A is the active center of lipopolysaccharide which also known as endotoxin. Monophosphoryl-lipid A (MPLA) has less toxicity but retains potent immunoadjuvant activity; therefore, it can be developed as adjuvant for improving the strength and duration of the immune response to antigens. However, MPLA cannot be chemically synthesized and can only be obtained by hydrolyzing lipopolysaccharid...
Treatment with a preparation of monophosphoryl lipid A, known to be capable of abolishing the expression of CD8+ suppressor T cell activity generated during the antibody response to type III pneumococcal polysaccharide (SSS-III), was found to have no adverse effect upon either induction or expression of CD8+ cytotoxic T lymphocyte activity specific for influenza A virus antigens. This suggests ...
SELECTIVE ACTIVATION OF p38 MAPK PATHWAY BY SYNTHETIC MONOPHOSPHORYL LIPID A 1 Caglar Cekic , Carolyn R. Casella, Chelsea A. Eaves, Atsushi Matsuzawa, Hidenori Ichijo, and Thomas C. Mitchell 2*† From the Department of Microbiology and Immunology and Institute for Cellular Therapeutics, University of Louisville School of Medicine, Louisville, KY 40202, and Laboratory of Cell Signaling, Graduate ...
Purpose: Staphylococcal enterotoxin B (SEB) is a potent inducer of cytotoxic T-cell activity, cytokine production and necrosis induction in vivo. Monophosphoryl lipid A (MPL) is an adjuvant derived from the lipopolysaccharide of E.coli, Salmonella Minnesota Re595 and other gram negative bacteria.Materials and Methods: In this research, The antitumor and antimetastatic effect of intra-venus inje...
Haemophilus ducreyi, the etiological agent of chancroid, has a strict requirement for heme, which it acquires from its only natural host, humans. Previously, we showed that a vaccine preparation containing the native hemoglobin receptor HgbA purified from H. ducreyi class I strain 35000HP (nHgbAI) and administered with Freund's adjuvant provided complete protection against a homologous challeng...
An efficient approach for the facile synthesis of a potent vaccine adjuvant RC-529 is described. The synthetic strategy relies on flexible use orthogonal protecting groups, which makes it possible to accomplish selective phosphorylation, glycosylation and acylation, respectively. In addition, readily cleaved 2-naphthylmethyl (Nap) ether allyl esters as permanent groups greatly facilitates final...
One potential strategy for the prevention of HIV infection is to induce virus specific mucosal antibody that can act as an immune barrier to prevent transmission. The mucosal application of chemokines after immunisation, termed "prime-pull", has been shown to recruit T cells to mucosal sites. We wished to determine whether this strategy could be used to increase B cells and antibody in the vagi...
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