In this study, the various core sizes of manganese ferrite nanoparticles(MnFe2O4) conjugated with D4 peptide (MnFe2O4-PEG-D4) were synthesized. The highrelaxivityMnFe2O4 nanoparticles were obtained by thermal decomposition of Iron acetylacetonate and manganese acetylacetonate in hydrophobic solution athigh boiling process. The surface ofMnFe2O4 nanoparticles were coated ...

To be effective for cytoplasmic delivery of therapeutics, nanoparticles (NPs) taken up via endocytic pathways must efficiently transport across the cell membrane and subsequently escape from the secondary endosomes. We hypothesized that the biomechanical and thermodynamic interactions of NPs with plasma and endosomal membrane lipids are involved in these processes. Using model plasma and endoso...

A series of first-row-transition-metal ferrite magnetic nanoparticles (NPs) MFe2O4 [M = Mn2+ (1), Fe2+ (2), Co2+ (3), Ni2+ (4), Cu2+ (5) or Zn2+ (6)] were prepared by the co-precipitation method and characterized by Fourier transform infrared (FTIR) spectroscopy, powder X-ray diffraction (XRD), scanning electron microscope energy dispersive X-ray spectrometry (SEM-EDS), vibrating sample magneto...

objective(s):  although several chemical and physical methods for gene delivery have been introduced, their cytotoxicity, non-specific immune responses and the lack of biodegradability remain the main issues. in this study, hydroxyapatite nanoparticles (nps) and 1,2-dioleoyl-sn-glycero-3-phosphoethanol​amine (dope)-modified hydroxyapatite nps was coated with antisense oligonucleotide of e6 mrna...

background: the current study aimed to determine the effect and properties of surface-modified copper doped cu:zno nps on killing curves of bacterial pathogens. m ethods:   preparation  of   in  situ   surface-modified  copper  doped  zno nanoparticles (cu:zno nps) was done according to standard procedure.assay for antimicrobial activity of cu:zno nps against bacterial pathogens was carried out...

PURPOSE The interaction of Porphyromonas gingivalis with commensal streptococci promotes P. gingivalis colonization of the oral cavity. We previously showed that a synthetic peptide (BAR) derived from Streptococcus gordonii potently inhibited the formation of P. gingivalis/S. gordonii biofilms (IC50 =1.3 µM) and reduced P. gingivalis virulence in a mouse model of periodontitis. Thus, BAR repres...

A multimodal target specific probe consisting of a biocompatible magnetic nanoparticle capable of altering the MR signal intensity, a NIR fluorochrome and a biological moiety that possess lock-and-key interactions can provide consistent in vivo imaging information with high sensitivity and spatial resolution. We have synthesized magnesium doped iron oxide nanoparticle as MR enhancer by thermal ...

A nanoparticle (NP) was developed to target choroidal neovascularization (CNV) via topical ocular administration. The NPs were prepared through conjugation of internalizing arginine-glycine-aspartic acid RGD (iRGD; Ac-CCRGDKGPDC) and transactivated transcription (TAT) (RKKRRQRRRC) peptide to polymerized ethylene glycol and lactic-co-glycolic acid. The iRGD sequence can specifically bind with in...

Tumor angiogenesis plays very important roles for tumorigenesis, tumor development, metastasis, and prognosis. Targeting T1/T2 dual modality magnetic resonance (MR) imaging of the tumor vascular endothelial cells (TVECs) with MR molecular probes can greatly improve diagnostic sensitivity and specificity, as well as helping to make an early diagnosis of tumor at the preclinical stage. In this st...