BACKGROUND This study aimed to explore demographic characteristics and clinical presentations of celiac disease (CD) in Northeastern Iran. METHODS This was a cross-sectional retrospective study of 193 adults with CD who presented to Mashhad University Gastroenterology Clinic between 2008 and 2013. Patient data that included mode of presentation and the presence of any concomitant illnesses were...

background: celiac disease (cd) has been found in up to 10% of the patients presenting with unexplained abnormal liver function tests (lft). as there is no precise data from our country in this regard, we investigated the prevalence of cd in patients presenting with abnormal lft. methods: from 2003 to 2008, we measured iga anti-tissue transglutaminase (t-tg) antibody (with elisa technique) with...

The objective of the study was to determine the diagnostic accuracy of anti-EMA antibody in comparison to histopathological findings in patients suspected of CD. This cross-sectional study was conducted at Gastroenterology Department, Fatima Memorial Hospital, Lahore, from March to October 2014. One hundred and twenty-one patients aged between 5 - 60 years of either gender were recruited in the...

individuals with particular genetic backgrounds develop immune responses to wheat proteins and become ‘gluten-sensitised’. mucosal pathology arises through activated mucosal t lymphocytes, resulting in a graded, adverse e reaction between particular genes and wheat proteins. given these varied influences, the marsh classification broadly itemises those stages through which a normal mucosa (mars...

The rebuttal of Oberhuber’s sub-division of Marsh III type in celiac disease (1) and its subsequent correspondence in the past and present issues of GHFBB allow us to review the current thinking on the histopathological classification of celiac disease. In the Definition of Medicine, Avicenna argues: -“While some divide medicine into a theoretical and a practical [applied] science, others may a...

BACKGROUND Recent guidelines have proposed that there is a correlation between tissue transglutaminase (tTG) antibody titers and degrees of duodenal biopsy, and that duodenal biopsy can be omitted in some patients with high levels of tTG antibody. Using data of registered patients in a gastrointestinal clinic we aimed to assess the correlation between tissue transglutaminase antibody with duode...

We read with interest the paper entitled “Mucosal histopathology in celiac disease: a rebuttal of Oberhuber ́s sub-division of Marsh III” by MN Marsh et al. published in this Journal (1). We have proposed a standardized classification system of the celiac lesions in 1999 (2).In their paper Marsh et al. comment on this work. To our surprise, the authors of the paper suggest that the flat mucosa (...

Objective. The prevalence of Celiac Disease (CD) is high in Iran, and evaluation of CD is not part of the routine screening procedure for dyspeptic patients; therefore, cases of occult CD may be missed. This study aimed to investigate the prevalence of occult CD among dyspeptic patients who presented at a gastroenterology clinic in the Western region of Iran. Methods. In this descriptive, cross...

Introduction Celiac disease (CD) is defined by gluten-induced immune-mediated enteropathy, affecting approximately 1% of the genetically predisposed population. The immunologic response to gluten causes characteristic intestinal alterations with gradual development. Histologic recovery of intestinal architecture was reported to occur within 6-12 months after starting a gluten-free diet, simulta...