*1 School of Mechanical Engineering, Pusan National University, San 30, Jangjeon-dong, Geumjeong-gu, Busan 609-735, Republic of Korea. *2 Department of Naval Architecture and Ocean Engineering, Pusan National University, San 30, Jangjeon-dong, Geumjeong-gu, Busan 609-735, Republic of Korea. *3 Advanced Ship Engineering Research Center (ASERC), Pusan National University, San 30, Jangjeon-dong, G...

STO-609, a selective inhibitor of Ca(2+)/calmodulin-dependent protein kinase kinase (CaM-KK) was synthesized, and its inhibitory properties were investigated both in vitro and in vivo. STO-609 inhibits the activities of recombinant CaM-KK alpha and CaM-KK beta isoforms, with K(i) values of 80 and 15 ng/ml, respectively, and also inhibits their autophosphorylation activities. Comparison of the i...

| An IC implementation for a demonstrator of adaptive beamforming in radio astronomy is presented here. The chip implements the MVDR (Minimum Variance Distortion-less Response) beamforming algorithm using Cordic arithmetic. It is designed in Mentor Graphics's DSP design environment (DSP station). In the beam-forming demonstrator, signals from 16 antennas are digitized at a sampling frequency of...

We investigated the transforming activity of the ret proto-oncogene with a mutation in cysteine 609, 611, 618, 620, 630, or 634 detected in patients with multiple endocrine neoplasia type 2A (MEN 2A), familial medullary thyroid carcinoma (FMTC), or Hirschsprung's disease. Of these cysteine mutations, codon 634 mutations are known to be correlated with the development of MEN 2A, whereas codon 60...

INTRODUCTION .............................................................. 609 MATERIALS AND METHODS ...................... ........................... 609 Media..................................................................... 609 Strains .................................................................... 609 S. typhimurium ............................................................. 609...

We investigatedthe transformingactivityofthe ret proto-oncogenewith a mutation in cysteine 609, 611, 618, 620, 630, or 634 detected in patients with multiple endocrine neoplasia type 2A (MEN 2A), familial meduilary thyroid carcinoma (FMTC), or Hirschsprung's disease. Of these cysteine mutations, codon 634 mutations are known to he correlated with the development of MEN 2A, whereas codon 609, 61...

a Department of Biological Sciences, Pusan National University, Busan 609–735, South Korea b Institute of Environmental Technology & Industry, Pusan National University, Busan 609–735, South Korea c Department of Environmental Education, Sunchon National University, Suncheon, Jeonnam 540-742, South Korea d Department of Environmental Science and Engineering, Kyung-Hee University, Yongin, Gyeong...

Metabolic enzymes involved in benzene activation or detoxification, including NAD(P)H, quinone oxidoreductase 1 (NQO1), cytochrome P450 2E1 (CYP2E1), myeloperoxidase (MPO), glutathione-S-transferase mu-1 (GSTM1), and glutathione-S-transferase theta-1 (GSTT1), were studied for their roles in human susceptibility to benzene poisoning. The potential interactions of these metabolic enzymes with lif...

We studied the pharmacological characteristics of HSR-609 (3-[4-(8-fluoro-5,11-dihydrobenz[b]oxepino[4,3-b]pyridin-11- ylidene)- piperidino]propionic acid dihydrate), a novel amphoteric antiallergic agent, on the central nervous system (CNS). Its selectivity for the histamine H1-receptor and its ability to penetrate into the CNS were compared with those of typical antiallergic agents and the no...