OBJECTIVE Endogenous insulin secretion, measured by C-peptide area under the curve (AUC), can be tested using both the glucagon stimulation test (GST) and the mixed-meal tolerance test (MMTT). This study compares these two stimulation methods using long-term data from patients newly diagnosed with type 1 diabetes or with latent autoimmune diabetes. RESEARCH DESIGN AND METHODS A recently compl...

OBJECTIVE Stimulated serum C-peptide (sCP) during a mixed-meal tolerance test (MMTT) is the gold standard measure of endogenous insulin secretion, but practical issues limit its use. We assessed urine C-peptide creatinine ratio (UCPCR) as an alternative. RESEARCH DESIGN AND METHODS Seventy-two type 1 diabetic patients (age of diagnosis median 14 years [interquartile range 10-22]; diabetes dur...

Immune intervention trials in type 1 diabetes have shown very mixed, and often surprising, results. Despite suggestions of benefit from GAD-Alum vaccine in a phase 2 study (1), further studies, including two large phase 3 trials, showed no effect (2–4). Phase 3 trials with Anti-CD3 monoclonal antibodies failed to achieve their primary outcome (5–7), despite very promising results from multiple ...

In healthy subjects, it has been suggested that exercise may acutely suppress energy-intake and appetite, with peak intensity being an important determinant for this effect. In subjects with type 2 diabetes (T2D), the effect of exercise on appetite-related variables is, however, virtually unknown. We aimed to assess the effects of two exercise interventions, differing with regards to peak inten...

Trauma and stressor-related disorders, including post-traumatic stress disorder (PTSD) and related comorbid disorders such as anxiety, depression, and dissociative disorders, are difficult to treat. Mindfulness-based clinical interventions have proven efficacy for mental health treatment in face-to-face individual and group modalities, although the feasibility and efficacy of delivering these i...

a selective and sensitive method for determination of cadmium and zinc is presented. the method is based on adsorptive accumulation of the complexes of cd (ii) and zn (ii) ions with 4-amiono-5-methyl-2,4-dihydro-3h-1,2,4-triazol-3-tion (mmtt) onto hanging mercury drop electrode (hmde), followed by reduction of the adsorbed species by voltammetric scan using differential pulse modulation. the li...

The beta score, a composite measure of beta cell function after islet transplantation, has limited sensitivity because of its categorical nature and requires a mixed-meal tolerance test (MMTT). We developed a novel score based on a single fasting blood sample. The BETA-2 score used stepwise forward linear regression incorporating glucose (in millimoles per liter), C-peptide (in nanomoles per li...

BACKGROUND The concurrent use of a postprandial insulin sensitizing agent, such as bromocriptine-QR, a quick release formulation of bromocriptine, a dopamine D2 receptor agonist, may offer a strategy to improve glycemic control and limit/reduce insulin requirement in type 2 diabetes (T2DM) patients on high-dose insulin. This open label pilot study evaluated this potential utility of bromocripti...

Changes in the clinical presentation of diabetes mellitus in childhood and adolescence associated with obesity have resulted in an overlap of the two most common types of diabetes with a greater clinical heterogeneity. In order to characterize the type of diabetes at onset and assess the effect of obesity, 50 children with diabetes were studied. The patients were divided into two groups accordi...

This work describes the design of a DSP (Digital Signal Processor) based Adaptive Numerical Mho relay, to be used for distance protection schemes of long distance transmission lines. The relay settings will be automatically adjusted with the changes of power system parameters with the variation of frequency as well as with the variation of percentage compensation which may occur due to fault /d...