BACKGROUND A potential mechanism for left ventricular (LV) remodeling after myocardial infarction (MI) is activation of the matrix metalloproteinases (MMPs). This study examined the effects of MMP inhibition (MMPi) on regional LV geometry and MMP levels after MI. METHODS AND RESULTS In pigs instrumented with radiopaque markers to measure regional myocardial geometry, MI was created by ligatin...

McKinley & Hathaway (1940) published the Hypochondriasis or Hs Scale as a means of understanding physical symptoms reported by the patient. They also developed the Hysteria or Hy scale (McKinley & Hathaway, 1944) to measure the expression of physical complaints in the context of hysteroid personality characteristics (e.g. denial). Hundreds of articles have been published on the use of the MMPI ...

What is there about the MMPI scales that make them the most frequently used measures in assessing parents in child custody evaluations? The extensive research detailing the instruments’ validity and effectiveness is highlighted to illustrate the empirical basis of the test in this application. Early research with the MMPI on parental behavior and problems established the test’s utility in under...

The Keane, Malloy, & Fairbank (1984) MMPI-PTSD Scale has proven to be a reliable and valid measure of posttraumatic stress disorder (PTSD) in combat veterans. However, few studies have examined the MMPI-PTSD Scale's validity in civilian trauma victims, including battered women. In the present study, 46 battered women who completed the MMPI-PTSD Scale were assigned to PTSD-Positive and PTSD-Nega...

Demonstrating the effect of the volunteer factor on Minnesota Multiphasic Personality Inventory (MMPI) profiles of addicts and nonaddicts, Gendreau and Gendreau suggested that previously reported MMPI differences between these two subject groups might well be explained by the "volunteer" status of the addict group. This article describes more thoroughly the unincarcerated addict sample, almost ...

What is there about the MMPI scales that make them the most frequently used measures in assessing parents in child custody evaluations? The extensive research detailing the instruments’ validity and effectiveness is highlighted to illustrate the empirical basis of the test in this application. Early research with the MMPI on parental behavior and problems established the test’s utility in under...

A substantial body of research suggests that the MMPI-2 contains a number of items that are sensitive to closed-head trauma (CHT) and other neurologic conditions. A correction procedure was recommended by Gass (1991) using an index consisting of 14 neurologically sensitive items that were extracted from a predominantly male veteran sample of CHT patients. The generalizability of these correctio...

The matrix metalloproteinases (MMPs) are an endogenous family of proteolytic enzymes implicated to contribute to LV remodeling. However, broad-spectrum MMP inhibition (MMPi), particularly inhibition of interstitial collagenase (MMP-1), may not be clinically applicable. This study examined the effects of selective MMPi (sparing MMP-1) in a model of developing congestive heart failure. Pigs were ...

This study assessed aspects of the construct validity of the Multidimensional Personality Questionnaire (MPQ), a measure of normal personality characteristics, in a clinically relevant sample through joint factor analyses of primary and second-order scales of the MPQ and the Minnesota Multiphasic Personality Inventory (MMPI). A subsample from the Washington University Twin Study of Psychopathol...