Upregulation of matrix metalloproteinases (MMPs), in particular MMP-2 and MMP-9 contributes to secondary pathogenesis of spinal cord injury (SCI) via promoting inflammation. Recently, we reported that trehalose suppresses inflammatory responses following SCI. Therefore, we investigated the effect of trehalose on MMP-2 and MMP-9 expression in SCI. A weight-drop contusion SCI was induced in male ...

in the human genome, chromosome 11 contains a cluster of matrix metalloproteinase (mmp) genes. single nucleotide polymorphisms in the promoter region of mmp genes are important for mmp expression. a common adenine deletion polymorphism (5a) at position -1171 of the mmp-3 gene promoter (5´-aaaaaaccat-3´ change to 5´-aaaaaccat-3´) facilitates transcriptional factor binding and mmp-3 promoter acti...

Background Around 8–10% of individuals over 50 years age present interstitial lung abnormalities (ILAs), but their risk factors are uncertain. Methods From 817 recruited in our ageing programme at the Mexican National Institute Respiratory Diseases, 80 (9.7%) showed ILAs and were compared with 564 same cohort normal high-resolution computed tomography to evaluate demographic functional differen...

Dilated cardiomyopathy (DCM) is accompanied by myocytes and connective tissue changes. Matrix metalloproteinases (MMPs) play important roles in cardiac remodeling. It seems that the gelatinases (MMP-2 and MMP-9) are effective enzymes in cardiomyopathy. Dilated cardiomyopathy was confirmed in 22 dogs (patient group) including 11 female and 11 male by clinical examination, auscultation, thoracic ...

conclusions our results suggest that tetracyclines dose-dependently inhibit mmp-9 activity, and among the common clinical tetracyclines, minocycline provides the most potent inhibition of excess mmp-9 activity and its consequences. materials and methods an mmp-9-rich culture medium of u-937 cells was used as the source of the enzyme. serial dilutions of 5, 20, 100, 200, and 500 µm of each drug ...