The objective of this study was to determine potential mechanisms of apoptotic activity of gemcitabine, a pyrimidine nucleoside analogue, in the MM1.S multiple myeloma (MM) cell line. A MM cell line that is sensitive to glucocorticoids (MM1.S) was used for this study. Immunoblotting analysis, cell cycle assays, and annexin V staining were performed to determine whether gemcitabine induced apopt...

We have characterized a temperate phage (MM1) from a clinical isolate of the multiply antibiotic-resistant Spanish/American 23F Streptococcus pneumoniae clone (Spain(23F)-1 strain). The 40-kb double-stranded genome of MM1 has been isolated as a DNA-protein complex. The use of MM1 DNA as a probe revealed that the phage genome is integrated in the host chromosome. The host and phage attachment si...

this paper analyzes an m/m/2 queueing system with two heterogeneous servers. both servers goes on vacation when there is no customers waiting for service after this server 1 is always available but the other goes on vacation whenever server 2 is idle. the vacationing server however, returns to serve at a low rate as an arrival finds the other server busy. the system is analyzed in the steady st...

We consider the queueing maximal covering location-allocation problem (QM-CLAP) with an M/M/1 queueing system. We propose a new solution procedure based on decomposition of the problem into smaller sub-problems. We solve the resulting sub-problems both with a branch and bound algorithm and with the meta-heuristic GRASP. We also solve the entire model with GRASP. Computational results for these ...

    Discrete facility location,   Distribution center,   Logistics,   Inventory policy,   Queueing theory,   Markov processes, The distribution center location problem is a crucial question for logistics decision makers. The optimization of these decisions needs careful attention to the fixed facility costs, inventory costs, transportation costs and customer responsiveness. In this paper we stu...

The fragmentation of a molecular cloud that leads to the formation high-mass stars occurs on hierarchy different spatial scales. large clouds harbour massive clumps with cores embedded in them. these may determine initial mass function and masses final stars. Therefore, studying processes is crucial understand how form. hot core G34-MM1, IRDC G34.34+00.24 located at distance 3.6 kpc, promising ...

A single server finite population queueing model with compulsory server vacation and with fixed batch service has been considered. For this model the system steady state probabilities are obtained. Some performance measures are calculated and numerical examples are also given.  

The central nervous system produces growth factors that stimulate proliferation of ameboid microglia during embryogenesis and after traumatic injury. Two microglial mitogens (MMs) are recovered from the brain of newborn rat. MM1 has an approximate molecular mass of 50 kD and a pI of approximately 6.8; MM2 has a molecular mass of 22 kD and a pI of approximately 5.2. These trypsin-sensitive prote...

CH3CN (J=6-5) was observed with a resolution of 2” toward W75N using the BIMA interferometer. Two continuum sources were detected at 3 mm, designated MM1 and MM2 in previous studies. Alignment of two mm continuum sources with the outflow axis from MM1 suggests that these continuum sources may be the result of the outflow interacting with the interstellar medium. MM1 is coincident with compact C...

MM creatine kinase purified from tissue exists as a single form but upon release into the plasma exhibits three forms which, based on increasing anodal migration on polyacrylamide gel electrophoresis, are referred to as MM1, MM2, and MM3. The three forms were isolated in pure form from plasma in sufficient quantities for biochemical and physiological studies. Chromatofocusing results show that ...