The authors explore likelihood-based methods for making inferences about the components of variance in a general normal mixed linear model. In particular, they use local asymptotic approximations to construct confidence intervals for the components of variance when the components are close to the boundary of the parameter space. In the process, they explore the question of how to profile the re...

background and aims: diabetes type ii (non-insulin dependent) which is one of the most prevalent diabetes types in the world emerges in people with the age of above 55 and genetic and environmental factors interfere in this disease. the aim of this study was to determine the factors affecting diabetes type ii with generalized mixed linear model. methods: population of this study included 2820 p...

Stochastic differential equations have been shown useful in describing random continuous time processes. Biomedical experiments often imply repeated measurements on a series of experimental units and differences between units can be represented by incorporating random effects into the model. When both system noise and random effects are considered, stochastic differential mixed-effects models e...