introduction: this study was performed to determine the efficacy of mitomycin c on synechia after fess in ethmoid sinuses in patients admitted in imam-khomeini hospital in 2011 and 2012. methods: in this interventional study, 30 patients with pan rhinosinusitis attending to imam-khomeini hospital in 2011 and 2012 were enrolled and in one side after fess, the mitomycin c and in the other side th...

Studies made of the treatment with 66 courses of mitomycin C in 28 patients with chronic myelogenous leukemia are reported. The effect of mitomycin C was investigated according to the relation between drug and host factors, comparison with the effects of other agents, and drug resistance. Patients with less hematological and clinical symptoms responded better to mitomycin C therapy. The remissi...

AIM To investigate the effect of trabeculectomy with and without mitomycin C in post-keratoplasty glaucoma. METHODS A retrospective study was performed on patients who underwent trabeculectomy for glaucoma after penetrating keratoplasty. 34 eyes of 32 patients were included in this study. 26 eyes received trabeculectomy with mitomycin C and eight eyes without mitomycin C. The procedure was de...

Mitomycin C reduced with sodium borohydride Induced the DNA damage at deoxyguanosines preferentially in dinucleotide sequence G-T. The DNA damage produced strand breaks when subsequently heated. The DNA damage scarcely occurred when the end-labeled DNA was preincubated with ethidium brotmde or actinomycin D before the addition of mitomydn C and the reducing agent. Fully reduced mitomycin C did ...

The role of DT-diaphorase in bioreductive activation of mitomycin C was examined using HT-29 and BE human carcinoma cells which have high and low levels of DT-diaphorase activity, respectively. HT-29 cells were more sensitive to mitomycin C-induced cytotoxicity than the DT-diaphorase-deficient BE cell line. Mitomycin C induced DNA interstrand cross-linking in HT-29 cells but not in BE cells. Bo...

purpose: to compare the success rate of mitomycin-c versus bevacizumab for prevention of bleb failure following phacotrabeculectomy. method: in this study 74 eyes of 69 patients with uncontrolled iop, progressive visual field loss and cataract were randomized in two groups. in the first group, after conjunctival peritomy at the sclera flap site, sponge pats soaked in mitomycin c with concentrat...

purpose: to compare the efficacy and safety of topical mitomycin-c (mmc) drops versus subconjunctival 5-fluourouracil (5-fu) injections for management of early bleb failure after trabeculectomy or combined phacoemulsification and trabeculectomy with posterior chamber intraocular lens implantation (pt+pciol). methods: in a comparative study, 37 eyes of 37 patients with impending early bleb failu...