نتایج جستجو برای: mitochondrial damage
تعداد نتایج: 349971 فیلتر نتایج به سال:
Mitochondria plays a major role in maintaining homeostasis of heart cells. Mitochondria produce ATP and is the main intracellular source of reactive oxygen species (ROS) which can cause oxidative damage. Free oxygen radicals and oxidative damage are associated with cardiovascular pathology. Antioxidant defense can play an essential role in preventing oxidative damage by controlling free oxygen ...
In this experiment, wheat plants were exposed to drought stress during seed development then we worked on the obtained seeds. The seed mitochondrial ultra-structure, and antioxidant enzymes in seedling were investigated after exposure to seed accelerated ageing. Drought stress during seed development induced some changes in mitochondrial ultra-structure. Encountering seed development to drought...
In this experiment, wheat plants were exposed to drought stress during seed development then we worked on the obtained seeds. The seed mitochondrial ultra-structure, and antioxidant enzymes in seedling were investigated after exposure to seed accelerated ageing. Drought stress during seed development induced some changes in mitochondrial ultra-structure. Encountering seed development to drought...
Considerable evidence suggests that mitochondrial dysfunction contributes to the toxicity of uranyl acetate (UA), a soluble salt of depleted uranium (DU). We examined the ability of the two antioxidants, beta-glucan and butylated hydroxyl toluene (BHT), to prevent UA-induced mitochondrial dysfunction using rat-isolated kidney mitochondria. Beta-glucan (150 nM) and BHT (20 nM) attenuated UA-indu...
Considerable evidence suggests that mitochondrial dysfunction contributes to the toxicity of uranyl acetate (UA), a soluble salt of depleted uranium (DU). We examined the ability of the two antioxidants, beta-glucan and butylated hydroxyl toluene (BHT), to prevent UA-induced mitochondrial dysfunction using rat-isolated kidney mitochondria. Beta-glucan (150 nM) and BHT (20 nM) attenuated UA-indu...
Background and purpose: Diabetes is a health problem worldwide with increasing prevalence in most countries. Nephropathy is a common microvascular complication of diabetes. Diabetes is directly associated with oxidative stress and mitochondrial damage that result in renal tissue damage. This study evaluated the efficiency of nanoceria in attenuation of oxidative damage in renal isolated mitocho...
6- mercaptopurine (6-mp) is widely used in clinic as an immunosuppressive for treatment of acute lymphocytic leukemia, crohn's disease, and ulcerative colitis with documented unpredictable hepatotoxicity. the potential molecular cytotoxic mechanisms of 6-mp against isolated rat hepatocytes were searched in this study using “accelerated cytotoxicity mechanism screening (acms)” techniques. t...
glaucoma is the second leading cause of irreversible blindness and a neurodegenerative disease with a complex pathogenesis. increasing evidence suggests that oxidative stress and mitochondrial dysfunction have crucial roles in most neurodegenerative diseases such as glaucoma. the conventional clinical treatment for glaucoma is lowering the intraocular pressure (iop). some patients have normal i...
6- Mercaptopurine (6-MP) is widely used in clinic as an immunosuppressive for treatment of acute lymphocytic leukemia, Crohn's disease, and ulcerative colitis with documented unpredictable hepatotoxicity. The potential molecular cytotoxic mechanisms of 6-MP against isolated rat hepatocytes were searched in this study using “Accelerated Cytotoxicity Mechanism Screening (ACMS)” techniques. The co...
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