To visualize intratumoral hypoxic areas and their reoxygenation before and during fractionated radiation therapy (RT), (18)F-fluoromisonidazole positron emission tomography and computed tomography (F-MISO PET/CT) were performed. A total of 10 patients, consisting of four with head and neck cancers, four with gastrointestinal cancers, one with lung cancer, and one with uterine cancer, were inclu...

We have used the technique of alkaline elution to determine the amount of nitrogen mustard (HN2)-induced DNA cross-linking in a murine fibrosarcoma tumor in vivo. Mice were either treated with HN2 directly or were pretreated with misonidazole (MISO) or diethyl maléateprior to injection with HN2. Two types of HN2induced DNA lesions were detected, namely, proteinase K-sensitive and -resistant cr...

Both misonidazole (MISO) and hyperthermia are known to enhance the radiation response of hypoxic cells, and to be selectively cytotoxic against cells in a hypoxic and acidic environment. The ability of these conditions to modify the effect of irradiation and their individual relationship was studied in a C3H mammary carcinoma and its surrounding skin. Simultaneous treatment with MISO, hyperther...

Misonidazole (MISO), a hypoxic cell radiosensitizer, has been shown in vivo to enhance tumor cell killing by melphalan (LPAM) with little or no enhancement of normal tissue injury. A Phase I trial was conducted using MISO p.o. 2 hr before i.v. LPAM. The highest doses used were the single maximum tolerated doses of MISO, 4 g/sq m, and LPAM, 0.6 mg/kg. Thirty-five patients were entered; 30 were e...

-Skin reactions on irradiated mouse feet were used to measure the radiosensitization of normal tissues by misonidazole (MISO). Fractionation schedules of 1, 2, 5 and 10 daily doses of X-rays were combined with either 100 mg/kg or 670 mg/kg MISO. When unanaesthetized mice were irradiated in air, significant sensitization was observed with both the high and low drug doses, in all fractionation sc...

BACKGROUND AND HYPOSESIS Soybean isoflavones have been shown to reduce the risk of cerebral infarction in humans according to epidemiological studies. However, whether intake of miso can reduce the incidence of stroke in animal models remains unknown. In this study, we investigated the effects of soybean paste (miso) in an animal model of stroke. METHODS Stroke-prone spontaneously hypertensiv...

Misonidazole (MISO) has previously been shown to enhance the antitumor effect of many chemotherapeutic drugs, in partic ular the bifunctional alkylating agents, in vivo without similarly increasing normal tissue toxicity. The presence of hypoxic cells in solid tumors may account for the preferential effect, since chemosensitization in vitro only occurs when cells are exposed to MISO under hypox...

The effect of combining the radiosensitizer misonidazole (MISO) with 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) prior to radiation on the response of various KHT sarcoma cell subpopulations was evaluated. Centrifugal elutriation was used to obtain homogeneous populations of cells with respect to their cell cycle position from suspensions prepared directly from treated solid KHT tumors....

A novel space-user approach to multiple-input-single-output (MISO) OFDM peak-to-average-power ratio (PAPR) reduction is examined. We propose two techniques that significantly reduce PAPR for MISO-OFDM at various userloads. The first exploits the degrees of freedom in the channel’s null-space (transmit weight optimization), while the second provides a more robust and higher reduction by further ...

Inverse scattering from discrete targets with the single-input–multiple-output (SIMO), multiple-input–single-output (MISO) or multiple-input–multipleoutput (MIMO) measurements is analyzed by compressed sensing theory with and without the Born approximation. High-frequency analysis of (probabilistic) recoverability by the L1-based minimization/regularization principles is presented. In the absen...