نتایج جستجو برای: mirnas
تعداد نتایج: 19044 فیلتر نتایج به سال:
استفاده از لایه فیدر و سایتوکین ها سبب افزایش خود تجدیدی و مهار تمایز سلول های بنیادی خون ساز می شودلذا ما بران شدیم تا در حضور لایه فیدر تغییرات بیان ژن های p53 و c-myc و mirnas این ژن ها را بسنجیم . لذا با استفاده از تکنیک real-time pcr بیان ژن های p53 و c-myc و mir-22 ،mir-145،mir-34a و mir-33a را سنجیدیم. در حضور لایه فیدر بیان ژن ها و mirnas تغییراتی از خود نشان دادند.
p 61: microrna as a therapeutic tool to prevent blood brain barrier dysfunction in neuroinflammation
endothelial cells present in brain are unique and differ from other peripheral tissues in a number of ways, which ensures specific brain endothelial barrier properties. endothelial dysfunction is the earliest event in the initiation of vascular damage caused by inflammation. various micrornas (mirna) have been discovered in different cellular components of the blood bran barrier (bbb). mirnas a...
conclusions the identified expression profiles of some examined mirnas might offer important points to consider for the treatment of naive patients and the management of chronically infected hcv patients in egypt and around the world. results our results revealed differential expression levels of the analyzed mirnas compared to the normal controls. twenty-seven mirnas (including mir-105, mir-14...
Objective(s): The purpose of this study was to conduct a meta-analysis on human microRNAs (miRNAs) expression data of endometriosis tissue profiles versus those of normal controls and to identify novel putative diagnostic markers. Materials andMethods: PubMed, Embase, Web of Science, Ovid Medline were used to search for endometriosis miRNA expression profiling studies of endometriosis. The miRN...
MicroRNAs (miRNAs) are severely protected sequences and single stranded structures approximately 18 to 25 nucleotides in length. The crucial role of miRNAs has been previously proved in the regulation of the gene expression in post transcriptional modification events of messenger RNA. The precise mechanism by which miRNAs modulate translational repression of mRNAs is not fully determined. Howev...
bladder cancer is the fifth most common cancer with significant morbidity and mortality. recently, numerous studies demonstrated that micrornas are emerging as diagnostic biomarkers for bladder cancer. specific mirna profiles have been identified for several samples from patients with bladder cancer. micrornas are noncoding rna molecules of approximately 23 nucleotides that play important roles...
as an aromatic and colorful plant of substantive taste, saffron (crocus sativus l.) owes such properties of matter to growing class of the secondary metabolites derived from the carotenoids, apocarotenoids. regarding the critical role of micrornas in secondary metabolic synthesis and the limited number of identified mirnas in c. sativus, on the other hand, one may see the point how the characte...
microrna modulation during the in vitro culture of hematopoietic stem cells prior to transplantation
background: human umbilical cord blood (hucb) is an acceptable and readily accessible source of stem cells. there is an ongoing interest in cord blood stem cell therapies; however, little is known about the possible unfavorable effects of laboratory modifications on the isolated hucb cells. the involvement of mirnas in several biological processes has been shown. the aim of this study was to ev...
Many studies have investigated misregulation of miRNAs relevant to multiple sclerosis (MS) pathogenesis. Abnormal miRNAs can be used both as candidate biomarker for MS diagnosis and understanding the disease miRNA-mRNA regulatory network. In this comprehensive study, misregulated miRNAs related to MS were collected from existing literature, databases and via in silico prediction. A multi-staged...
MicroRNAs (miRNAs) are small non-coding RNAs that have functional roles in post-transcriptional modification. They regulate gene expression by an RNA interfering pathway through cleavage or inhibition of the translation of target mRNA. Numerous miRNAs have been described for their important functions in developmental processes in numerous animals, but there is limited information about sheep an...
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