Dosimetry for targeted radionuclide therapy is a relatively young field. Although initial work can be traced back to the late 1940s (1), the MIRD Committee formalism that forms the foundation for most current approaches was published in the mid 1970s (2), and the drive for improved dosimetry to meet the requirements of targeted radionuclide therapy did not begin until the 1980s. During this per...

The reliability of radiation dose estimates in internal radionuclide therapy is directly related to the accuracy of activity estimates obtained at each imaging time point. The recently published MIRD pamphlet no. 23 provided a general overview of quantitative SPECT imaging for dosimetry. The present document is the first in a series of isotope-specific guidelines that will follow MIRD 23 and fo...

Mathematical models for kinetics of radiopharmaceuticals in humans were developed and are used to estimate the radiation absorbed dose for patients in nuclear medicine by the International Commission on Radiological Protection and the Medical Internal Radiation Dose (MIRD) Committee. However, due to the fact that the residence times used were derived from different subjects, partially even with...

UNLABELLED The contribution to red marrow absorbed dose from beta-emitting radionuclides distributed uniformly in the total body can be overestimated using either MIRD 11 or MIRDOSE3. The S value assigned to the red marrow target region from activity distributed in the remainder of the body is of particular concern. The assumption that the specific absorbed fraction for total body irradiating r...

Introduction: In patients with thyroid carcinoma, radiation absorbed doses of the thyroid and surrounding tissues is important to weigh risk and benefit considerations. In nuclear medicine, the accuracy of absorbed dose of internally distributed radionuclides is estimated by different methods such as MIRD and direct method using TLD. The aim of this study is using TLD and a phantom to determine...

introduction: radioactive materials deliver internal radiation dose to patients in nuclear medicine. manual internal radiation dose assessment is a complicated method. introduction of a simple dose calculation software is the main goal of the present study. methods: using the best current data in internal dose calculation (s-factors) recommended by icrp and by considering other technical metho...