introduction: radioiodine therapy is an effective method for treating thyroid cancer carcinoma, but it has some affects on normal tissues, hence dosimetry of vital organs are important to weigh the risks and benefits of this method. the aim of this study is to measure the absorbed doses of important organs by mcnp (monte carlo n particle) simulation and comparing the results of different method...

Background: Radioiodine therapy has proven to be an effective method in the treatment of patients with differentiated thyroid carcinoma after thyroidectomy. The scope of this study is to describe a method to obtain the dose of organs using medical internal radiation dosimetry (MIRD) method. At the end, the results of MIRD calculations were compared with thermoluminescent dosimeter (TLD...

Background: Reliable estimation of radiation-absorbed dose is necessary to evaluate the benefits and the risks of radiopharmaceuticals used for diagnostic or therapeutic purposes in nuclear medicine. Materiel and Methods: This study included 47 patients treated with iodine-131 for Graves’ disease. A comparative study between Geant4 Monte Carlo simulation and MIRD formalism was carried out to ev...

This paper describes the mathematical efficiency calibration of the whole-body counter at Forschungszentrum Jülich using Monte Carlo codes and mathematical anthropomorphic phantoms. As a prerequisite for the Monte Carlo simulations a precise model of the 4 high-purity germanium (HPGe) detectors had to be developed. Because the technical data provided by the manufacturer were not sufficient for ...

BACKGROUND RADIOIODINE IS ROUTINELY USED OR PROPOSED FOR DIAGNOSTIC AND THERAPEUTIC PURPOSES: (123)I, (125)I and (131)I for diagnostics and (125)I and (131)I for therapy. When radioiodine-labelled pharmaceuticals are administered to the body, radioiodide might be released into the circulation and taken up by the thyroid gland, which may then be an organ at risk. The aim of this study was to com...

H arold L. Atkins, MD, was presented with the LoevingerBerman Award for excellence in the field of internal dosimetry on Sunday, June 15, at the SNM Annual Meeting in New Orleans, LA. The award was established in 1999 by the Medical Internal Radiation Dose (MIRD) Committee in honor of Robert Loevinger and Mones Berman, who formulated the MIRD schema for internal dose calculations. The award is ...

Introduction: Spatial dose distribution around the radionuclides sources is required for optimized treatment planning in radioimmunotherapy. At present, the main source of data for cellular dosimetry is the s-values provided by MIRD. However, the MIRD s-values have been calculated based on analytical formula in which no electrons straggling is taken to account. In this study, we used Geant4-DNA...

introduction: spatial dose distribution around the radionuclides sources is required for optimized treatment planning in radioimmunotherapy. at present, the main source of data for cellular dosimetry is the s-values provided by mird. however, the mird s-values have been calculated based on analytical formula in which no electrons straggling is taken to account. in this study, we used geant4-dna...

Background: Radioiodine is routinely used or proposed for diagnostic and therapeutic purposes: I, I and I for diagnostics and I and I for therapy. When radioiodine-labelled pharmaceuticals are administered to the body, radioiodide might be released into the circulation and taken up by the thyroid gland, which may then be an organ at risk. The aim of this study was to compare dosimetric properti...

Therapy with 90Y-microspheres is emerging as a mainstream treatment modality in the management of patients with primary and metastatic liver cancer (1,2). The technique involves the administration of 90Y-microspheres into the hepatic artery, which is accessed via the transfemoral route or through a hepatic arterial infusion port or pump. The technique was first introduced by Ariel, who also rep...