نتایج جستجو برای: mir 26
تعداد نتایج: 207749 فیلتر نتایج به سال:
BACKGROUND Although pituitary adenoma is a malignant tumor, it can present as invasive growth in some cases. MicroRNA (miR)-26a has been found to be abnormally highly expressed in pituitary adenoma, indicating possible involvement in pathogenesis. As a known target gene of miR-26a, PLAG1 has abnormally low expression in pituitary adenoma. The correlation between miR-26a or PLAG1 expressional ab...
Objectives We aimed to examine the performance of stem cell markers and epithelial-mesenchymal transition (EMT) process in miR-145 transfected EWS cells (TC71, TC106). Methods were utilized for functional analysis mir-145. Proliferation, migration, invasion soft agar colony assay performed observe alterations migration behavior cells. Caspase was used investigate underlying reasons proliferativ...
High dietary SBM content is known to induce important physiological alterations, hampering its use as a major FM alternative. Rainbow trout (Oncorhynchus mykiss) juveniles were fed two experimental diets during 9 weeks: (i) diet containing 12% FM; and (ii) vegetable meal (VM) totally devoid of based on (26%). Fish the VM did not show reduced growth performance when compared with fish diet. Neve...
The role of miRNAs – small, regulatory, noncoding RNAs in the multiple sclerosis (MS) development is being intensively investigated. Previously, we first who observed a significant increase expression 26 microRNA genes localized DLK1-DIO3 locus men with relapsing-remitting MS (RRMS) peripheral blood mononuclear cells (PBMCs), using RNA sequencing. Objective: to evaluate possible involvement reg...
مقدمه: لوسمی لنفوبلاستی حاد سلولt (t-all) حاصل نقص در بلوغ پیشتاز سلول t به سلول t بالغ می باشد. t-all یکی از انواع بدخیمی های خونی است که پیش آگهی ضعیفی دارد. به منظور دستیابی به یک روش درمانی موفق، درک و شناخت بیولوژی تکامل سلول t و مولکول هایی که در این فرایند تکاملی شرکت دارند ضروری می باشد. در این مطالعه، از رده سلولی jurkat t، که برای بررسی آزمایشگاهی t-all به عنوان سلول های مدل اثبات شده...
Hepatocellular carcinoma (HCC) generally possesses a high resistance to chemotherapy. Given that autophagy is an important factor promoting tumor chemoresistance and HCC express low level of miR-26, we aim to investigate the functional role of miR-26 in autophagy-mediated chemoresistance of HCC. We found that chemotherapeutic drug doxorubicin (Dox) induced autophagy but decreased the level of m...
Two different levels' information fusion of near infrared (NIR) spectra and mid infrared (MIR) spectra coming from red wines aged in different ways has been investigated. A total of 96 red wines, including 44 wines aged in oak barrel, 26 wines aged in stainless steel tank with oak chips and 26 wines aged in stainless steel tank, were analyzed. The NIR transmission spectra and MIR attenuated tot...
BACKGROUND & AIMS Adjuvant therapies for hepatocellular carcinoma (HCC) such as interferon-alpha are effective only in a subset of patients. Previously we found that HCC patients with low level of miR-26 have survival benefits from interferon-alpha. The purpose of this study is to develop a standardized miR-26 diagnostic test (referred as MIR26-DX) to assist identification of candidate HCC pati...
The functional association between intronic miRNAs and their host genes is still largely unknown. We found that three gene loci, which produced miR-26a and miR-26b, were embedded within introns of genes coding for the proteins of carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase (CTDSP) family, including CTDSPL, CTDSP2 and CTDSP1. We conducted serum starvation-stimulatio...
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