BACKGROUND The bone mineral content of premature infants at term is lower than in mature infants at the same postconceptional age. Serum alkaline phosphatase and serum phosphate are often used as indicators of bone mineralisation. OBJECTIVE To analyse the association between bone mineral content and serum alkaline phosphatase and serum phosphate. METHODS Serum alkaline phosphatase and phosp...

The present studies show that the previously reported ability of fetuin to inhibit the precipitation of hydroxyapatite from supersaturated solutions of calcium and phosphate in vitro is accompanied by the formation of the fetuin-mineral complex, a high molecular mass complex of calcium phosphate mineral and the proteins fetuin and matrix Gla protein that was initially discovered in the serum of...

Introduction: Phosphate is among the nutrients considered critical for all known life [1-4]. The ion is a component in ATP, DNA, RNA, phospholipid cell membranes and required in numerous fundamental biochemical reactions [5]. Phosphorus, either as phosphate or a more reduced species such as phosphite, is also considered crucial in pre-biotic reactions that may have led to the origin of life on ...

The hydroxyapatite (HAP) with variable chemical substitutions has been considered as the major component in the mineralized part of bones. Various metastable crystalline phases have been suggested as transitory precursors of HAP in bone, but there are no consensuses as to the nature of these phases and their temporal evolution. In the present study, we cultured rat calvarial osteoblasts with as...

introduction : the aim of this in vitro study was to evaluate the effect of smear layer on the push-out bond strength of white mineral trioxide aggregate (wmta) with and without disodium hydrogen phosphate (na 2 hpo 4 ). materials and methods: dentin discs with standard cavities were obtained from extracted human single-rooted teeth and divided to 4 groups ( n =15) according to the irrigation r...

A field experiment was carried out in the Research and Production Station, National Research Center, El-Nobaria during the season, 2009 to evaluate the effect of cobalt and different sources of phosphorus fertilizers on the growth, yield quantity and quality of tomato. Treatments can be arranged in descending order as follows: Mono super phosphate (MSP) > Triple super phosphate (TSP) > Rock pho...

The incidence of cardiovascular events and mortality strongly correlates with serum phosphate in individuals with CKD. The Npt2b transporter contributes to maintaining phosphate homeostasis in the setting of normal renal function, but its role in CKD-associated hyperphosphatemia is not well understood. Here, we used adenine to induce uremia in both Npt2b-deficient and wild-type mice. Compared w...

The serum levels of calcium (Ca) and phosphate are maintained higher in the fetus than in the pregnant mother, especially in late gestation, to meet the demands of fetal bone development. In order to maintain this fetal stage-specific mineral homeostasis, the placenta plays a critical role through active transcellular mineral transport. Although the molecular mechanism of transplacental Ca tran...

INTRODUCTION A Phosphate Centric Forum, supported by Genzyme Corporation, was held on 24–25 June, 2010 at the Sheraton West Park Hotel, Munich, Germany, in which 25 medical and scientifi c experts in the fi eld of chronic kidney disease-related mineral and bone disorder (CKD-MBD) met to present and discuss the central role of phosphate in the development of CKD-MBD, on which research has now ce...