background: the existence of a pathophysiological link between headaches and muscle activity pattern is still being debated. the purpose of this study was to investigate the effect of pain on the timing pattern of the masseter muscle in patients with tension-type headache (tth) and migraine without aura (moa). methods: 57 women (22 controls, 19 moa and 16 tth) participated in the study. the ele...

OBJECTIVE This study examined the association between vascular headaches and retinal microvascular disease. METHODS We investigated the cross-sectional association between headaches (migraine/other headaches with aura, migraine without aura, other headaches without aura, no headaches) and retinal microvascular signs (retinopathy, focal arteriolar narrowing, arteriovenous nicking; arteriolar a...

BACKGROUND AND PURPOSE Our aim in this study was to compare headache-free and spontaneous migraine measurements of blood flow velocity and the pulsatility index in the anterior cerebral artery, middle cerebral artery, and posterior cerebral artery. METHODS Thirty-one patients (nine having experienced migraine with aura and 22 migraine without aura) were studied in headache-free periods and du...

Background and Purpose—Previous P–magnetic resonance spectroscopy (P-MRS) studies have shown that cerebral cortical energy metabolism is abnormal in migraine and that cortical energy reserves decrease with increasing severity and duration of aura. Migrainous infarction is a rare complication of migraine with aura, and its pathophysiology is poorly understood. We used P-MRS to determine whether ...

OBJECTIVE  To evaluate whether patients with migraine are at increased risk of perioperative ischemic stroke and whether this may lead to an increased hospital readmission rate. DESIGN  Prospective hospital registry study. SETTING  Massachusetts General Hospital and two satellite campuses between January 2007 and August 2014. PARTICIPANTS  124 558 surgical patients (mean age 52.6 years; 5...

In this issue of Cephalalgia, Dr Jakob Moller Hansen and his colleagues report a series of very interesting experiments in which they successfully induced migraine-like attacks in patients with migraine with aura via infusion of calcitonin gene related peptide (CGRP). This work echoes similar experiments carried out by the Copenhagen group using the nitric oxide donor, glycerol trinitrate (GTN)...

Migraine is a common episodic brain disorder characterized by recurrent attacks of disabling headache.(1) In one-third of patients, headache is preceded or accompanied by aura symptoms, which are transient and fully reversible hemispheric neurologic symptoms. In the absence of any objective marker, the diagnosis of migraine is clinical and based on the criteria proposed by the International Hea...

Background Calcitonin gene-related peptide provokes migraine attacks in 65% of patients with migraine without aura. Whether aggregation of migraine in first-degree relatives (family load) or a high number of risk-conferring single nucleotide polymorphisms contributes to migraine susceptibility to calcitonin gene-related peptide infusion in migraine patients is unknown. We hypothesized that gene...

OBJECTIVE To compare the prevalence of an incomplete circle of Willis in patients with migraine with aura, migraine without aura, and control subjects, and correlate circle of Willis variations with alterations in cerebral perfusion. METHODS Migraine with aura, migraine without aura, and control subjects were prospectively enrolled in a 1∶1∶1 ratio. Magnetic resonance angiography was performe...