Recent studies suggest that migraine may be associated with gastrointestinal (GI) disorders, including irritable bowel syndrome (IBS), inflammatory bowel syndrome, and celiac disease. Here, an overview of the associations between migraine and GI disorders is presented, as well as possible mechanistic links and clinical implications. People who regularly experience GI symptoms have a higher prev...

Migraine is a common neurological disorder that affects 11% of adults worldwide. This disease most likely has a neurovascular origin. Migraine with aura (MA) and more common form - migraine without aura (MO) - are the two main clinical subtypes of disease. The exact pathomechanism of migraine is still unknown, but it is thought that both genetic and environmental factors are involved in this pa...

Defining disease status in population-based studies is often challenging, particularly when disease status changes between active and non-active stages. Migraine is a typical example of a fluctuating disease as its frequency and clinical features can vary considerably during one’s lifespan (1). In general, the data show that the vast majority of patients have an onset of their migraine in child...

OBJECTIVES To evaluate whether the association between migraine with aura and increased risk of cardiovascular disease is modified by vascular risk groups as measured by the Framingham risk score for coronary heart disease. DESIGN Prospective cohort study. SETTING Women's health study, United States. PARTICIPANTS 27 519 women who were free from cardiovascular disease at baseline with avai...

OBJECTIVE To evaluate the association between migraine and cardiovascular disease, including stroke, myocardial infarction, and death due to cardiovascular disease. DESIGN Systematic review and meta-analysis. DATA SOURCES Electronic databases (PubMed, Embase, Cochrane Library) and reference lists of included studies and reviews published until January 2009. Selection criteria Case-control a...

background: migraine is a chronic disease that affects nearly 6% of men and 18% of women worldwide. there are various drugs, which can successfully decrease migraine symptoms and frequency of migraine attacks, but these drugs usually are expensive. hence, this study aimed to assess the effects of pyridoxine  supplementation on severity, frequency and duration of migraine attacks as well as head...

Migraine is a constellation of neurological symptoms with variable disease progression. Despite the standardization of migraine diagnosis with the International Headache Society (IHS) criteria, its etiology eludes medical research because its complexity as a disease lies in the multiple factors involved in migraine onset. The study of migraine genetics is providing important clues to the pathop...

Migraine is a disabling neurological disorder, diagnosis of which based on clinical criteria. A shortcoming these criteria that they do not fully capture the heterogeneity migraine, including underlying genetic and neurobiological factors. This complexity has generated momentum for biomarker research to improve disease characterisation identify novel drug targets. In this Series paper, we prese...