PURPOSE The aim of this study was to determine the progressive processes of polymorphic transformation of different gabapentin (GBP) polymorphs by using hot-stage Fourier transform infrared (FTIR) microspectroscopy. METHODS Four polymorphs of GBP were previously prepared and then identified by differential scanning calorimetry (DSC), thermogravimetric (TG) analysis, FTIR microspectroscopy and...

‘5”., By S RGIo DE CARVALHO T HIS PAPER PRESENTS some results of the absorption microspectroscopy of bone marrow cells in two main wave lengths: 4150 A (violet region in the Soret band) and 2650 A (UV). The first wave length is indicative of heme structures in appreciable concentration in cells.” 2 As these are only achieved as Hb, the Soret hand absorption microspectroscopy becomes specific fo...

Chemical imaging is a technique for the simultaneous measurement of spectra (chemical information) and images or pictures (spatial information)[1][2] The technique is most often applied to either solid or gel samples, and has applications in chemistry, biology[3][4][5] [6][7][8], medicine[9][10], pharmacy[11] (see also for example: Chemical Imaging Without Dyeing), food science, biotechnology[1...

Raman microspectroscopy measurements were performed on Hayabusa sample RA-QD02-0197. The sample has been provided by JAXA to our consortium in the scope of the 1 International Announcement of Opportunity [1]. Raman microspectroscopy is an appropriate technique for a contactless mineralogical investigation and is applied to describe the mineralogical composition of the sample. For the noble gas ...

BACKGROUND Analysis of pollen grains reveals valuable information on biology, ecology, forensics, climate change, insect migration, food sources and aeroallergens. Vibrational (infrared and Raman) spectroscopies offer chemical characterization of pollen via identifiable spectral features without any sample pretreatment. We have compared the level of chemical information that can be obtained by ...

metronidazole is used to treat trichomoniasis, bacterial vaginosis, and other diseases. there are controversy aspects about its teratogenicity. a teratogenic agent can alter morphology or subsequent function of the fetus. the aim of this study was to examine an alternative method for the recognition of the mechanism or the bimolecular potential changes in mice fetus caused by metronidazole usin...

A multimodal multiphoton nonlinear optical (NLO) microspectroscopy imaging system was developed using a femtosecond laser and a photonic crystal fiber. Coherent anti-Stokes Raman scattering (CARS) microspectroscopy was combined with two-photon excitation fluorescence and second-harmonic generation microscopy in one platform and the system was applied to diagnose liver fibrosis. Normal and liver...

Monitoring extracellular matrix (ECM) components is one of the key methods used to determine tissue quality in three-dimensional scaffolds for regenerative medicine and clinical purposes. Raman spectroscopy can be used for non-invasive sensing of cellular and ECM biochemistry. We have investigated the use of conventional (confocal and semiconfocal) Raman microspectroscopy and fibre-optic Raman ...

The dentino-enamel junction (DEJ) connects enamel, that covers the outer surface of a tooth, to a thicker underlying dentin. The DEJ is a critical interface that permits joining these materials that have widely dissimilar mechanical properties. AFM-based nanoindentation and Raman microspectroscopy were used to define the width and composition of human molar DEJ. Indentation elastic modulus and ...