Optimization of geometry and surface modification of microchip input reservoirs were performed to achieve uninterferenced pressure-induced sample injection of multiple samples into microreactors using a single syringe pump. Nine samples of 3.5 microL were pipetted onto input reservoirs and loading of PCR mixture into 260 nL microreactors was achieved followed by successful PCR amplification, co...

The unique operational characteristics of microreactors are described in this article, with particular reference to their use as tools for chemical synthesis. With reference to the future automation, an example is presented to illustrate how microreactors can be readily integrated into current HPLC systems, to enable fully integrated chemical synthesis and product analysis to be performed.

ASSOCIATED INFECTION OF MEDICAL IMPLANTS J.-H. Lee, H. Wang, M. Libera, and W.Y. Lee Stevens Institute of Technology, USA ABSTRACT This paper reports the exploration of microfabricated bioreactors (“microreactors”), as new in vitro tools for studying the complexity of biofilm-associated infection of implantable medical devices. We designed, fabricated, and evaluated microreactors in an iterativ...

A new method for catalyst deposition on the inner walls of capillary microreactors is proposed which allows exact control of the coating thickness, pore size of the support, metal particle size, and metal loading. The wall-coated microreactors have been tested in a selective hydrogenation reaction. Activity and selectivity reach values close to those obtained with a homogeneous Pd catalyst. The...

Recently, extensive studies have been carried out on micro chemical process technologies (Jensen, 2001; Fletcher et al., 2002). In particular, analysis of chemical reactions and transport phenomena in micro-space has been performed energetically. However, most microreactors are designed and fabricated by trial and error -there is no systematic procedure for developing microreactors. Therefore, ...

We report a device to fill an array of small chemical reaction chambers (microreactors) with reagent and then seal them using pressurized viscous liquid acting through a flexible membrane. The device enables multiple, independent chemical reactions involving free floating intermediate molecules without interference from neighboring reactions or external environments. The device is validated by ...

Molecular-sieve zeolites, Nafion membranes, low-density polyethylene films, and mixed surfactant vesicles have been used as microreactors to carry out organic photochemical reactions. The photo-cycloadditions of diaryl compounds with long flexible chains included in NaY zeolite or low-density polyethylene films yield intramolecular photocyclomers to the exclusion of intermolecular products. The...

Combining reaction and detection in multiphase microfluidic flow is becoming increasingly important for accelerating process development in microreactors. We report the coupling of UV/Vis spectroscopy with microreactors for online process analysis under segmented flow conditions. Two integration schemes are presented: one uses a cross-type flow-through cell subsequent to a capillary microreacto...

Miniaturized microreactors enable photochemistry with laser irradiation in flow mode to convert azidobiphenyl into carbazole with high efficiency.