In this work, rising of a single bubble in a quiescent liquid under microgravity condition was simulated. The related unsteady incompressible full Navier-Stokes equations were solved using a conventional finite difference method with a structured staggered grid. The interface was tracked explicitly by connected marker points via hybrid front capturing and tracking method. One field approximatio...

An in vitro organotypic culture model is needed to understand the complexities of carcinoma tissue consisting of carcinoma cells, stromal cells, and extracellular matrices. We developed a new in vitro model of carcinoma tissue using a rotary cell culture system with four disposable vessels (RCCS-4D) that provides a simulated microgravity condition. Solid collagen gels containing human pancreati...

In the present study, we discovered that mouse oocyte maturation was inhibited by simulated microgravity via disturbing spindle organization. We cultured mouse oocytes under microgravity condition simulated by NASA's rotary cell culture system, examined the maturation rate and observed the spindle morphology (organization of cytoskeleton) during the mouse oocytes meiotic maturation. While the r...

BACKGROUND There is limited and inconclusive evidence that space environment, especially microgravity condition, may affect microstructure of human brain. This experiment hypothesized that there would be modifications in gray matter (GM) and white matter (WM) of the brain due to microgravity. METHOD Eighteen male volunteers were recruited and fourteen volunteers underwent -6° head-down bed re...

Long-term spaceflights will eventually become an inevitable occurrence. Previous studies have indicated that oral infectious diseases, including dental caries, were more prevalent in astronauts due to the effect of microgravity. However, the impact of the space environment, especially the microgravity environment, on the virulence factors of Streptococcus mutans, a major caries-associated bacte...

Microgravity has proved to be an ideal condition grow crystals. In article number 2101777, Raphael Pfattner, Tiago Sotto Mayor, Daniel Ruiz-Molina, Josep Puigmartí-Luis, and co-workers demonstrate how generate simulated microgravity on Earth 2D porous crystalline molecular frameworks such as metal–organic covalent organic frameworks.

INTRODUCTION The effect of reducing gravity on locomotion has been studied using microgravity analogues. However, there is no known literature comparing locomotion in actual microgravity (AM) to locomotion in simulated microgravity (SM). METHODS Five subjects were tested while walking at 1.34 m x s(-1) and running at 3.13 m x s(-1) on a treadmill during parabolic flight and on a microgravity ...

14 day-old mouse ovarian tissue and preantral follicles isolated from same-aged mice were incubated in a simulated microgravity culture system. We quantitatively assessed follicle survival, measured follicle and oocyte diameters, and examined ultrastructure of the oocytes produced from the system. We observed decreased follicle survival, downregulation of expressions of proliferating cell nucle...