Adipose-derived stem cells (ADSCs) are widely used for tissue engineering and regenerative medicine. The beneficial effects of ADSCs on wound healing have already been reported. Remodeling of extracellular matrix (ECM) is the most important physiological event during the wound healing. ECM is sensitive to mechanical stresses and the expression of its components can be therefore influenced. The ...

purpose: microgravity causes major changes in various systems of the body in space, such as shift in cerebrospinal fluid, decreased red blood cells count, and electrolyte loss. these complications are very important in space and we should find new approaches to prevent the side effects of microgravity in astronauts. materials and methods: this experimental study was conducted on 21 adult male r...

In the present study, we discovered that mouse oocyte maturation was inhibited by simulated microgravity via disturbing spindle organization. We cultured mouse oocytes under microgravity condition simulated by NASA's rotary cell culture system, examined the maturation rate and observed the spindle morphology (organization of cytoskeleton) during the mouse oocytes meiotic maturation. While the r...

Microgravity can affect many aspects of intestinal homeostasis, leading to an increased risk of colitis. Estrogen, the most frequently affected hormone when under simulated microgravity, regulates the permeability of the colonic mucosa barrier. The associations between alterations in intestinal microbiota and increased susceptibility under microgravity have not been thoroughly elucidated. The a...

NASA dedicated over 20 shuttle missions to microgravity research as a primary payload, and many more missions carried microgravity research experiments as secondary payloads. The space agency’s microgravity research strived to increase understanding of the effects of gravity on biological, chemical, and physical systems. Living systems benefited as well. Cells, as they adapted to microgravity, ...

background: revealing data on the role of vitamin d and calcium supplementation in bone health has led some to suggest that vitamin d and calcium treatment could also play a role in protecting bone against microgravity-induced mineral loss. objectives: the aim of the present study was to investigate the effects of vitamin d and calcium administration on microscopic and densitometric changes of ...

The purpose of this study was to examine the expression of nuclear and mitochondrial genes in cardiac and skeletal muscle (triceps brachii) in response to short-duration microgravity exposure. Six adult male rats were exposed to microgravity for 6 days and were compared with six ground-based control animals. We observed a significant 32% increase in heart malate dehydrogenase (MDH) enzyme activ...

OBJECTIVES To develop an animal model of rhinosinusitis in microgravity, to characterize the behavior of intracavitary fluid in microgravity, and to assess the accuracy of ultrasonographic (US) diagnosis in microgravity. DESIGN An animal model of acute sinusitis was developed in anesthetized swine by creating a window into a frontal sinus to allow unilateral catheter placement and injection o...

We examined the respiratory behaviours and swimming kinematics of Xenopus laevis tadpoles hatched in microgravity (Space Shuttle), simulated microgravity (clinostat) and hypergravity (3 g centrifuge). All observations were made in the normal 1 g environment. Previous research has shown that X. laevis raised in microgravity exhibit abnormalities in their lungs and vestibular system upon return t...