Microfluidic biochips are becoming more and more popular in biomedical laboratory and also industry. Different from the continuous-flow microfluidic systems, a new generation of microfluidic biochips, referred to as digital microfluidic chips, has evolved over time and it offers advantages such as on-line reconfiguration and fault-tolerant operation. The principles behind the digital microfluid...

A major challenge in tissue engineering is the lack of proper vascularization of the fabricated tissue constructs. Microscale technologies, especially microfluidic systems, provide new opportunities to overcome the challenge of developing artificial micro-vasculatures. In this chapter, the application of microfluidic systems for generating vascularized tissue constructs by using microfluidic pl...

This work demonstrates the development of microfluidic compact discs (CDs) for protein purification and fractionation integrating a series of microfluidic features, such as microreservoirs, microchannels, and microfluidic fractionators. The CDs were fabricated with polydimethylsiloxane (PDMS), and each device contained multiple identical microfluidic patterns. Each pattern employed a microfluid...

We introduce Synthetic Microfluidic Paper, a novel porous material for microfluidic applications that consists of an OSTE polymer that is photostructured in a well-controlled geometry of slanted and interlocked micropillars. We demonstrate the distinct benefits of Synthetic Microfluidic Paper over other porous microfluidic materials, such as nitrocellulose, traditional paper and straight microp...

Nowadays, researchers are focusing on sorting, characterizing and detecting micron or submicron particles or bacteria in microfluidic chips. However, some contradictions hinder the applications of conventional microfluidic chips, including the low working distance of high resolving power microscopy and the low light transmittance of conventional microfluidic chips. In this paper, a rapid and re...

This paper reports the fabrication of a biodegradable microfluidic device based on zein, a prolamin protein derived from corn. Micro-chambers and micro-channels features have been replicated on zein films using a stereo lithography master. Enclosed zein microfluidic devices are made by bonding the zein films with microfluidic features to glass substrates using a simple vapor-deposition method. ...

A three-dimensional (3D) microfluidic network plays an important role in engineering thick organs. However, most of the existing methods are limited to mechanically robust synthetic biomaterials and only planar or simple microfluidic networks have been incorporated into soft natural biopolymers. Here we presented an automatic layer-by-layer micromolding strategy to reproducibly fabricate 3D mic...

Ever increasing demand in modulation and integration of microfluidic devices, new and advanced fabrication method are required for expanding their capability in microfluidic researches. We report threedimensional (3D) printing technique for producing microfluidic modules and their assembly into functional microfluidic devices for non-expert users.

Microfluidic networks represent the milestone of microfluidic devices. Recent advancements in microfluidic technologies mandate complex designs where both hydraulic resistance and pressure drop across the microfluidic network are minimized, while wall shear stress is precisely mapped throughout the network. In this work, a combination of theoretical and modeling techniques is used to construct ...

The creation of complex three-dimensional (3D) microfluidic systems has attracted significant attention from both scientific and applied research communities. However, it is still a formidable challenge to build 3D microfluidic structures with arbitrary configurations using conventional planar lithographic fabrication methods. Here, we demonstrate rapid fabrication of high-aspect-ratio microflu...