Microcytosis is decrease of red blood cells (RBCs) size. The RBCs size is measured by the mean corpuscular volume (MCV). In the children, MCV varies by age and sex and so it must be always compared with sex and age-based norms. A MCV less than the 5 percentile defines the children microcytosis . The most frequent causes of microcytosis are iron deficiency anaemia (IDA) and haemoglobinopathies [...

The ethnic composition of the Brazilian population favors high frequencies of the -alpha3.7 deletion, responsible for alpha-thalassemia, because this mutation is very common in African populations. In spite of its importance, this hemoglobinopathy has been poorly investigated in Brazil, especially at the molecular level. We investigated the prevalence of the -alpha3.7 mutation in 220 individual...

Microcytosis is typically an incidental finding in asymptomatic patients who received a complete blood count for other reasons. The condition is defined as a mean corpuscular volume of less than 80 µm3 (80 fL) in adults. The most common causes of microcytosis are iron deficiency anemia and thalassemia trait. Other diagnoses to consider include anemia of chronic disease, lead toxicity, and sider...

  Background :Identification of α thalassemia (α thal) a common cause of microcytosis during neonatal periods is an important step prevent unnecessary interventions. Thus, low the mean corpuscular volume (MCV) and the mean corpuscular hemoglobin (MCH) may consider as α-thalassemia key detection points. The present study aimed to determine the prevalence of microcytosis among neonates who born i...

Microcytosis is a common hematological finding, usually related to iron deficiency or beta-thalassemia. When both of these conditions are excluded, alpha-thalassemia must be considered in the differential diagnosis. No simple biochemical test is able to diagnose the alpha-thalassemia trait. Using PCR amplification of the breakpoint in deletional forms, and amplification of the alpha 2 gene and ...

SYNDROMES are characterized by the unequal production of structurally normal globin subunits.’ Very few mutations of hemoglobin structure mimic the clinical phenotype of thaIassemia. The Lepore i5fl hemoglobins’2 and the elongated a-chain termination codon mutants3 are structural variants that are poorly synthesized, leading to erythrocyte microcytosis and conditions similar to heterozygous (3o...