Purpose: Various floating and pulsatile drug delivery systems suffer from variations in the gastric transit time affecting the bioavailability of drugs. The objective of the study was to develop Pantoprazole Sodium (PAN) microballoons that may prolong the gastric residence time and could enhance the drug bioavailability. Methods: Microballoons were prepared using Eudragit®L100 by adopting emuls...

PURPOSE A multiparticular floating-pulsatile drug delivery system was developed for time and site specific drug release of piroxicam. A blend of floating and pulsatile principles of drug delivery system would have the advantage that a drug can be released in the upper GI tract after a definite time period. METHODS Hollow microspheres were prepared by the emulsion solvent diffusion method usin...

Quasi-static and dynamic compression response of syntactic foam (SF)–aluminum foam interpenetrating phase composites (IPC) is examined. Infusion of uncured syntactic foam (epoxy filled with hollow microballoons) into an open-cell aluminum network results in a 3D interpenetrating structure upon curing. The compression responses are measured at strain rates of ∼0.001/s and 1500/s. The dynamic exp...

This study aims to develop a novel technique in manufacturing nanocomposite bimodal foams containing expandable polymeric microballoons. Low density polyethylene syntactic were prepared via injection molding process, afterwards, batch refoaming method was utilized create structure. The effects of microballoon and nanoclay content foaming time temperature on microstructure physical properties in...

A 3D interpenetrating phase composite (IPC) foammade by infusing syntactic foam (SF) into an open-cell aluminum scaffold is studied under high-strain rate conditions. The SF is prepared by dispersing hollow glass microballoons into an epoxy matrix. Dynamic compression characteristics, including strength and failure progression of pure SF and IPC foammade of four different volume fractions ofmic...

A multiple-unit oral floating system was prepared using the emulsification-solvent diffusion method to prolong the gastric emptying time of theophylline. For this purpose, theophylline, ethyl cellulose and dibutyl phthalate were dissolved in an ethanol/dichloromethane mixture, added to 0.1 M HCl containing NaCl (20%) or saturated theophylline and/or different concentrations of polysorbate 80 an...

Gas filled hollow microparticles, i.e., microbubbles and microballoons, are soft matter devices used in a number of diverse applications ranging from protein separation and purification in food science to drilling technology and ultrasound imaging. Aqueous dispersions of these mesoscopic systems are characterized by the stabilization of the air/water interface by a thin shell of phospholipid bi...