Background: Cadmium is a potent toxicant and carcinogenic in human and experimental animals. The evidence indicates that cadmium induces aberrant gene expression, inhibition of DNA damage repair, and apoptosis. In this study, we investigated the effects of IP (intraperitoneal) injection of cadmium on mRNA levels expression of Bcl-2 and Bax genes in rat small intestine. <s...

Introduction: Ghrelin is an endogenous peptide that has diverse functions in the body. One of the newly recognized roles of this peptide is its antiapoptotic effect. However, this function has not been investigated in normobaric hypoxia- induced apoptosis in body organs. This study will examine the effect of ghrelin treatment on Bax-Bcl-2 gene expression in the kidney of chronic hypoxic rats. ...

introduction: the amount of expression of bax and bcl-2 genes in infertile men’s sperm as well as its association with sperm parameters and dna fragmentation index is an issue which has not been studied yet. in this research, it is assumed that up-regulation of bax and downregulation of bcl-2 are directly associated with sperm dna fragmentation. methods: after obtaining semen samples from the p...

introduction: busulfan as a chemotherapeutic agent causes testicular germinal epithelium depletion and cytotoxicity in germ cells. the aim of this study was to assess antioxidant status, reactive oxygen species (ros) generation and apoptosis-related genetic markers of adult male mouse sperm following busulfan treatment. materials and methods: forty adult nmri mice (30 ± 5 g) were divided into t...

Introduction: Memory impairment is one of the complications of diabetes which may accompany with changes in expression of apoptotic and antiapoptotic genes. The aim of the present study was the evaluation of intra-hippocampal injection of aminoguanidine (AG), as an antioxidant and inducible nitric oxide synthase inhibitor, on passive avoidance memory and Bcl-2 family genes expression in diab...

Back ground: Although the cell differentiation is an inseparable part of development in multicellular organisms, the regulating molecular pathway of it still is not fully defined. In the other hand, apoptosis is a fundamental physiological process which plays an essential role in a variety of biological events during development. Moreover, recent studies have found that apoptosis shows several ...