Background The major histocompatibility complex (MHC) gene family, a vital immune family in vertebrates, helps animals defend against pathogens. polymorphism of MHC genes is important for species and considered to be caused by the numerous alleles antigen-presenting genes. However, mechanism this process unclear due lack data on structure. evolutionary trajectories tetrapod are also because ins...

Small cell lung cancer (SCLC) is a highly aggressive tumor with early primary resistance and modest clinical response to immune checkpoint blockade (ICB). Mutations or transcriptional repression of the major histocompatibility complex class I (MHC-I) represent key mechanism driving T cell-based therapies. Lysine-specific demethylase 1 (LSD1) regulates gene expression via demethylating lysines 4...

Major histocompatibility complex (MHC) molecules are key players in initiating immune responses towards invading pathogens. Both MHC class I and class II genes are present in teleosts, and, using phylogenetic clustering, sequences from both classes have been classified into various lineages. The polymorphic and classical MHC class I and class II gene sequences belong to the U and A lineages, re...

Abstract Major histocompatibility (MHC) bound viral peptides are the immune signatures to initiate selective and cross-reactive T cell responses. Identifying antigenic targets of adaptive immunity SARS-CoV-2 is a key towards understanding pathogenesis Sars-CoV-2 rapidly evolving mutants. We isolated immunopeptidomes identify naturally processed presented MHC-II (HLA-DR, HLA-DP) MHC-I (HLA-ABC) ...

To survive organisms must defend themselves against pathogens. Classical Major Histocompatibility Complex (MHC) genes play a key role in pathogen defense by encoding molecules involved recognition. MHC gene diversity influences the variety of pathogens individuals can recognize and respond to has consequently been popular genetic marker for disease resistance ecology evolution. However, is pred...

Studies of mice lacking MHC class I (MHC I)-associated proteins have demonstrated a role for MHC I in neurodevelopment. A central question arising from these observations is whether neuronal recognition of MHC I has specificity for the MHC I allele product and the peptide presented. Using a well-established embryonic retina explant system, we observed that picomolar levels of a recombinant self...

The MHC class I (MHC I) molecules play a pivotal role in the regulation of immune responses by presenting antigenic peptides to CTLs and by regulating cytolytic activities of NK cells. In this article, we show that MHC I A in rhesus macaques can be alternatively spliced, generating a novel MHC I A isoform (termed "MHC I A-sv1") devoid of α(3) domain. Despite the absence of β2-microglobulin (β2m...

Abstract T cell immunity to viruses and cancers is crucially dependent on the surface display of major histocompatibility complex class I (MHC-I) molecules selectively loaded with high affinity peptides. Peptide loading occurs in ER within a multimolecular assembly known as peptide (PLC). A critical component PLC tapasin, 45 kDa membrane glycoprotein whose absence expression stability MHC-I are...

Multiple vaccines were developed and administered to immunize people worldwide against SARS-CoV-2 infection. However, changes in platelet count following the course of vaccination have been reported by many studies, suggesting vaccine-induced thrombocytopenia. In this context, designing an effective targeted subunit vaccine with high specificity efficiency for low counts has become a challenge ...