Prolonged residence of drug formulation in the nasal cavity is important for the enhancing intranasal drug delivery. The objective of the present study was to develop a mucoadhesive in-situ gelling nasal insert which would enable the reduced nasal mucociliary clearance in order to improve the bioavailability of metoclopramide hydrochloride. Metoclopramide hydrochloride is a potent antiemetic...

Two simple, accurate, rapid and economical spectrophotometric methods have been developed for the simultaneous determination of paracetamol and metoclopramide hydrochloride from tablet dosage form. The first method developed employs formation and solving simultaneous equations using 248.6 nm and 275.6 nm as two wavelengths for formation of equations. Second method is absorbance ratio in which w...

There has been growing interest in the subject of drug delivery and the design and evaluation of controlled-release systems. The simplest way to control the release of an active agent is to disperse it in an inert polymeric matrix. Controlled-release systems are of interest because they are technologically simple, relatively cheap, and practically unaffected by physiological changes. In this st...

   Prolonged residence of drug formulation in the nasal cavity is important for the enhancing intranasal drug delivery. The objective of the present study was to develop a mucoadhesive in-situ gelling nasal insert which would enable the reduced nasal mucociliary clearance in order to improve the bioavailability of metoclopramide hydrochloride. Metoclopramide hydrochloride is a potent antiemetic...

A 26-year-old Malaysian woman (childbearing age) attended a private primary care clinic with known case of gastroesophageal reflux disease (GERD) and complained persistent nausea few episodes vomiting. She had no drug allergy, surgical history, hospitalization in the last two years, was non-smoker, history or alcohol abuse. The patient prescribed Tab metoclopramide 10 mg TDS ranitidine 150 BD f...

OBJECTIVE To compare the efficacy and safety of a small dose of propofol with other commonly used antiemetics, droperidol and metoclopramide, for the prevention of postoperative nausea and vomiting in patients undergoing middle ear surgery. DESIGN Prospective, randomized, double-blind study. SETTING University-affiliated teaching hospital. PATIENTS Ninety patients (48 females, 42 males) s...

The aim of this study is to evaluate the specificities of the irradiation of drugs in frozen aqueous solution. The structures of the degradation products were determined to gain insight into the radiolysis mechanisms occurring in frozen aqueous solutions. Metoclopramide hydrochloride and metoprolol tartrate were chosen as models. The frozen solutions were irradiated at dry ice temperature by hi...

Madam, cetirizine hydrochloride, an antihistamine, is the active constituent of Zyrtec® that functions as competitive peripheral H1 receptor inhibitor.1 Cetirizine is known to have reduced blood-brain barrier penetration due to its larger mass, lipophobic properties and increased attraction for peripheral H1 receptors. Oculogyric crisis is a neurologic impairment defined by bilateral dystonic, ...

Xylazine hydrochloride, α2 adrenoceptor agonist, is an analgesic, sedative, tranquilizer, and muscle relaxant agent in veterinary medicine which is mostly used as in pre-anesthesia in veterinary medicine. One of the main adverse effects of xylazine which limits application of this medication in small animal veterinary practice (mostly in cats) is nausea and vomiting which can end up with aspira...

Prolonged residence of drug formulation in the nasal cavity is important for the enhancing intranasal drug delivery. The objective of the present study was to develop a mucoadhesive in-situ gelling nasal insert which would enable the reduced nasal mucociliary clearance in order to improve the bioavailability of metoclopramide hydrochloride. Metoclopramide hydrochloride is a potent antiemetic an...