BACKGROUND Metoclopramide is a dopamine D2-receptor antagonist used as an antiemetic and gastroprokinetic agent in man and animals. The drug causes sedation as a side effect in man. Such a sedative action of metoclopramide has not been documented in the chicken as the drug is not used clinically in this species. The present study examines the central nervous system depressant effects of metoclo...

The prokinetic effect of metoclopramide is mediated through the blockade of enteric (neuronal and muscular) inhibitory dopamine D2 receptors, and metoclopramide has the ability to stimulate 5-HT3 and 5-HT4 receptors (2). Metoclopramide also exerts inhibitory effects on D2 receptors centrally (located outside the blood-brain barrier), and these contribute to its antiemetic effect. Metoclopramide...

OBJECTIVE To assess the evidence from controlled trials on the efficacy and tolerability of parenteral metoclopramide for acute migraine in adults. DATA SOURCES Cochrane Central Register of Controlled Trials, Medline, Embase, LILACS, CINAHL, conference proceedings, clinical practice guidelines, and other sources. SELECTION CRITERIA Randomised controlled trials of parenteral metoclopramide f...

OBJECTIVE Metoclopramide is the only medication widely used to promote gastrointestinal motility in the USA. Despite its appreciable risk of central nervous system complications, it continues to be prescribed to children for chronic use. We sought to estimate the prevalence of chronic metoclopramide use among US children and identify the diagnoses that may have prompted this use. The US metoclo...

BACKGROUND/AIMS Prokinetic drugs such as metoclopramide are frequently used as second-line therapy for patients with gastroesophageal reflux disease. However, their beneficial effects remain unclear. Esophageal motor activities and compliance of the esophagogastric junction (EGJ) are important for prevention of gastroesophageal reflux. Although metoclopramide has been reported to increase lower...

Thirty three untreated patients being given cisplatin received metoclopramide (7 mg/kg) for antiemesis by either continuous or intermittent infusion in a random order. Each patient received intravenous dexamethasone in addition. High pressure liquid chromatography was used to measure plasma concentrations of metoclopramide. The two regimens were evaluated for antiemetic efficacy and the inciden...

We have studied the effect of i.v. metoclopramide on renal vascular resistance in nine healthy volunteers. Peak systolic and end-diastolic frequencies were measured using duplex Doppler ultrasound of a renal interlobar artery, before and after the administration of i.v. metoclopramide 10 mg, and the resistance index derived. There was no significant change in mean arterial pressure or resistanc...

Introduction: Drug-induced acute dystonic reaction is a common presentation to emergency department. Oromandibular dystonia one of the focal dystonias, which can be presented as jaw clenching, opening or deviation and leads impaired speech swallowing. In this paper, we an adult patient with recurrent temporomandibular joint dislocation due metoclopramide use.
 Case Report: A 21-year-old fe...

introduction: nausea and vomiting are the most common complications after minor head trauma that increases the risk of intracranial pressure rising. therefore, the present study was aimed to compare the antiemetic effects of metoclopramide and ondansetron in the treatment of post-traumatic nausea and vomiting. methods: the study was a controlled, randomized, double blind clinical trial, which w...