Ogata, M., Takatsuka, Y., and Tomokuni, K. (1971). Brit. J. industr. Med., 28, 382-385. Excretion of hippuric acid and mor p-methylhippuric acid in the urine of persons exposed to vapours of toluene and mor p-xylene in an exposure chamber and in workshops, with specific reference to repeated exposures. Four male volunteers were exposed to 200 p.p.m. of toluene for five one-hour periods separate...

background : the aims of this study were evaluation of exposed to xylenes in low concentration and compare urinary level of methyl hippuric acid in taxi drivers and petrol stations workers in west of iran. methods: this observation study was carried out on samples of the exposed men to xylenes in two occupational groups in hamadan city (west of iran) from march 2003 to march 2004. subjects incl...

A gas chromatographic method for simultaneous determination of hippuric and o-, m-, and p-methylhippuric acids (metabolites of toluene and xylene) in urine is described. The analytical procedure is based on the extraction of the aromatic metabolites with ethyl acetate containing the internal standard and on a methylation with 3-methyl-1-p-tolyltriazene. With this method, which does not require ...

Absorption of m-xylene and excretion of m-methylhippuric acid were investigated under controlled conditions in ten volunteers aged 17-33 years. They were exposed to m-xylene vapours at concentrations of 100, 300, and 600 mg/m3. It was found that m-xylene vapour retained in the lungs tended to decrease at the end of the exposure. An exposure test was devised, based upon the results obtained duri...

A rapid and accurate quantitative method was developed and validated for the analysis of four urinary organic acids with nitrogen containing functional groups, formiminoglutamic acid (FIGLU), pyroglutamic acid (PYRGLU), 5-hydroxyindoleacetic acid (5-HIAA), and 2-methylhippuric acid (2-METHIP) by liquid chromatography tandem mass spectrometry (LC/MS/MS). The chromatography was developed using a ...

Mikulski, P. I., Wiglusz, Renata, Bublewska, Anna, and Uselis, J. (1972). Brit. J. industr. Med., 29, 450-453. Investigation of exposure of ships' painters to organic solvents. An analysis was carried out of the hazard to ships' painters working at different concentrations of toluene and xylene vapours in air. The authors point out that it is possible to use a joint determination of hippuric an...

There are numerous biomonitoring programs, both recent and ongoing, to evaluate environmental exposure of humans to chemicals. Due to the lack of exposure and kinetic data, the correlation of biomarker levels with exposure concentrations leads to difficulty in utilizing biomonitoring data for biological guidance values. Exposure reconstruction or reverse dosimetry is the retrospective interpret...