The 2-(methylamino) pyridine, L, reacts with CuCl in THF to give hexameric copper (I) complex, [CuCl(L)]6. The molecular structure has been determined by using single-crystal X-ray diffraction method. The complex crustallizes in the monoclinic space group P21/n with four molecules per unit cell. The unit cell dimensions are a = 8.3495 (15), b = 15.622 (6), and c = 17.0...

both as crystals and in solution.1–3 There are rare examples of trans amide of N-methyl aromatic anilide in crystals, though the introduction of methyl group(s) ortho to the amide bond reduces the ratio of the cis-amide form of N-methylbenzanilides in solution.3 In this paper, we report on the crystal structure of 1,2-bis(N-2-fluorobenzoyl-N-methylamino)benzene (1, Fig. 1), which has two trans-...

n, n΄-3, 4-di(methylamino)-1, 2, 5-oxadiazole (1f) was prepared by dehydration of n, n΄-3, 4-di(methylamino)glyoxime (2f) in aqueous potassium hydroxid at 170-180 ˚c. under similar conditions n, n΄-3, 4-di(benzylamino)-1, 2, 5-oxadiazole (1c) and n, n΄-3, 4-di(isopropylamino)-1, 2, 5-oxadiazole (1e) were not obtained, but, n, n΄-3, 4-di(ethylamino)-1, 2, 5-oxadiazole (1g) was appeared with smal...

Abstract Background [ 18 F]Fluoromisonidazole ([ F]FMISO) and 1-[ F]fluoro-3-((2-((1 E ,3 )-4-(6-(methylamino)pyridine-3-yl)buta-1,3-dien-1-yl)benzo[d]thiazol-6-yl)oxy)propan-2-ol F]PM-PBB3 or F]APN-1607) are clinically used radiotracers for imaging hypoxia tau pathology, respectively. Both were produced by direct F-fluorination using the corresponding tosylate precursors 1 2 F]F − , followed r...

A new 2-[(4-substituted-phenyl-3-chloroazetidin-2-one)-5-(2'-methylamino 4-phenyl-1', 3'-thiazolyl-]-1, 3, 4-thiadiazoles, 5(a-n) were synthesized from 2-substituted-benzylideneamino-5-[2'-methylamino-4'-phenyl-1',3'-thiazolyl]-1,3, 4-thiadiazole, 4(a-n) using 2-amino-4phenyl-1, 3-thiazole as a starting material. The synthesised compounds have been screened in vitro for their antimicrobial acti...

Selected 2,6-(disubstituted)purine 2',3'-didehydro-2',3'-dideoxynucleosides and 2',3'-dideoxynucleosides were prepared and evaluated. Treatment of 5'-protected ribonucleosides with phenoxythiocarbonyl chloride and 4-(dimethylamino)pyridine, or under Schotten-Baumann conditions, gave high yields of 2',3'-O-thionocarbonates that underwent Corey-Winter elimination. Treatment of unprotected ribonuc...

N, N΄-3, 4-di(methylamino)-1, 2, 5-oxadiazole (1f) was prepared by dehydration of N, N΄-3, 4-di(methylamino)glyoxime (2f) in aqueous potassium hydroxid at 170-180 ˚C. Under similar conditions N, N΄-3, 4-di(benzylamino)-1, 2, 5-oxadiazole (1c) and N, N΄-3, 4-di(isopropylamino)...

Cultures of actinomycete strain WRAT-210 produced a dark red crystalline metabolite which was named texazone. Spectroscopic evidence suggested that the structure of texazone is 2-(N-methylamino)-3H-phenoxazin-3-one-8-carboxylic acid. The structure was confirmed by chemical synthesis through oxidative dimerization of ethyl 3-amino-4-hydroxybenzoate with 2-(N-methylamino)phenol and subsequent hyd...