Methionine was found to be more efficient than formate, serine, bicarbonate, formaldehyde, or choline as a source of the C-28 methyl group of ergosterol in yeast (1). While transfer of an intact methyl group to carbon has not been previously recorded, oxidation of the methyl group of methionine to formate has been demonstrated and formate-Cl* has been shown to give rise to C-28 of ergosterol (2...

The mechanism of the (dpms)Pt(II)Me(OH(n))((2-n)-) oxidation in water to form (dpms)Pt(IV)Me(OH)2 and (dpms)Pt(IV)Me2(OH) complexes was analyzed using DFT calculations. At pH < 10, (dpms)Pt(II)Me(OH(n))((2-n)-) reacts with O2 to form a methyl Pt(IV)-OOH species with the methyl group trans to the pyridine nitrogen, which then reacts with (dpms)Pt(II)Me(OH(n))((2-n)-) to form 2 equiv of (dpms)Pt(...

Evidence from several fields of investigation lead to the hypothesis that the sulfur atom is involved in vitamin B12-dependent methyl group transfer. To compile the evidence, it is necessary to briefly review the following fields: methylation, the new field of sulfane sulfur/hydrogen sulfide (S°/H₂S), hydrosulfide derivatives of cobalamins, autoxidation of hydrosulfide radical, radical S-adenos...

It has been established from studies with Escherichia coli mutants (1,2) and animal liver (3,4) that 1\Is-methyltetrahydrofolic acid (5-CH3-folate-H4) transfers its methyl group to homocysteine to form methionine. The functions of the complex requirements for this reaction (reduced flavin (1,5), S-adenosylmethionine (AMe)l(4), and a cobalamin compound (6-8)) have not yet been fully elucidated. ...

atom transfer radical polymerization of styrene (st) and methyl methacrylate (mma) was performed at 90oc in the absence and presence of nanoclay (cloisite 30b). trichloromethyl-terminated poly(vinyl acetate) telomerand cucl/ pmdeta were used as a macroinitiator and catalyst system, respectively. the experimental results showed that the atom transfer radical polymerization of st and mma in the a...

We present evidence for methyl (as methyl or methoxy) transfer from the methyl-accepting chemotaxis proteins H1 and possibly H3 of Bacillus subtilis to the methyl-accepting chemotaxis protein H2. This methyl transfer, which has been observed in vitro (D. J. Goldman and G. W. Ordal, Biochemistry 23:2600-2606, 1984), was strongly stimulated by the chemoattractant aspartate and thus may play an im...