Background: Malignant melanoma is a highly metastatic cutaneous cancer and typically refractory to chemotherapy. Deregulated apoptosis has been identified as a major cause of cancer drug resistance, and upregulated expression of the inhibitor of apoptosis protein melanom, an inhibitor of apoptosis (ML-IAP) is frequent in melanoma. Methods: Based on the conclusion that ML-IAP expression contribu...

Malignant melanoma in children is rare. It can arise from congenital melanocytic nevi. In pediatric patients, diagnosis of melanoma is difficult and challenging because the physicians have a low index of suspicion. Marrow metastasis in malignant melanoma especially in children is extremely uncommon. Here, the authors reported a 5 year old girl who was presented with a 4 month history of pelvic ...

Melanoma is originating from melanocytes, it a malignant tumor with high metastatic potential. It the leading cause of moratlity skin cancer, Nail melanoma rare form melanoma. we report new case this localization

introduction: the incidence of malignant melanoma is increasing at a rate greater than any other human cancer. although melanoma accounts for only 4 percent of all dermatologic cancers, it is responsible for 80 percent of deaths from skin cancer; only 14 percent of patients with metastatic melanoma survive for five years. the optimal therapy varies with the stage of the disease. surgical excisi...

Cytokines influence cell cycle events, which in some but not all instances can be associated with melanoma progression. Analysis of the G0/G 1 and S phase fractions of the cell cycle was used to assay the proliferative or inhibitory activity of cytokines against ten human melanoma cell lines, including pairs of cell lines derived from primary and metastatic tissue of individual patients. Cy...

Melanoma incidence and survival are age-dependent, with older patients having both higher rates worse outcomes. Here, we seek to examine age-dependent differences in mutational profiles of cutaneous melanoma, which may impact melanoma prognosis treatment-related Mutational 2263 were extracted from the American Association for Cancer Research Project Genomics Evidence Neoplasia Information Excha...

A potential diagnostic pitfall in the management of patients with melanoma is the inability to recognize metastatic melanoma, especially if it shows unusual features. We describe a case of multiple epidermotropic metastatic melanoma, which finally recurred with an extensive chondroid differentiation. To our knowledge, this is the first description of a case of epidermotropic chondroid metastati...

Small bowel tumors are very rare. Melanoma in small intestine can be primary or metastatic. Metastatic malignant melanoma arise from skin, eyes, oropharynx, esophagus ano rectal mucosa. Primary melanomas of In this case report, we going to present intestine, which has already metastasized by the time presentation. A 60 year old male, presented us with abdominal pain, vomiting and absolute const...

Apoptosis-associated Speck-like protein containing a CARD (caspase recruitment domain) (ASC) was originally named because it triggered apoptosis in certain tumors. More recently, however, ASC was found to be a central adaptor protein of inflammasome, which mediates the secretion of protumorigenic inflammation. Here we examined the role of ASC in tumorigenesis of human melanoma. Compared with pr...

BACKGROUND The stomach is regarded as a rare site for metastasis. When a gastric mass is observed macroscopically, the presumed diagnosis is usually a primary gastric carcinoma. However, the stomach may be involved in metastatic malignant melanoma. Besides a possible macroscopical misdiagnosis, metastatic gastric melanoma may also be misdiagnosed microscopically as adenocarcinoma due to its pro...