نتایج جستجو برای: metalloprotease

تعداد نتایج: 3114  

2006
George E. Davis Brian M. Martin

The treatment of HL-60 promyelocytic leukemia cells with phorbol esters (12-O-tetradecanoylphorbol-13-acetate) results in the appearance of cell substrate adhesion and the release of a M, 94,000 gelatindegrading metalloprotease. The appearance of the metalloprotease in the culture medium directly correlates with the timing and extent of cell substrate adhesion over a 24-h period. Vini-W, 94,000...

Journal: :international journal of aquatic biology 0
biplab sarkar school of biotechnology, kiit school of biotechnology, kiit university, bhubaneswar 751024, india. manoj kumar school of biotechnology, kiit school of biotechnology, kiit university, bhubaneswar 751024, india. raja mansingh rathore school of biotechnology, kiit school of biotechnology, kiit university, bhubaneswar 751024, india. nutrimar as, norway suresh verma school of biotechnology, kiit school of biotechnology, kiit university, bhubaneswar 751024, india.

the present study was conducted to evaluate the effect of dietary inclusion of silver nanoparticle on general performance and digestive proteases in zebra fish. four experimental diets were designed with a concentration of 5, 20 and 40 parts per billion (ppb) nanoparticles in the diet (named s5, s20, and s40, respectively) and control group without any nanoparticles (s0). there was no significa...

A.J. Turner,

The zinc metalloprotease, neprilysin (NEP), plays a role in the metabolism of cardiovascular, inflammatory and neuropeptides, including mitogenic peptides such as bombesin. In the cardiovascular system, NEP has a primary role in the inactivation of natriuretic peptides but also contributes to local metabolism of angiotensin, endothelins and bradykinin. Hence NEP is seen as a potential therapeut...

Journal: :Applied and environmental microbiology 2008
Johan Binesse Claude Delsert Denis Saulnier Marie-Christine Champomier-Vergès Monique Zagorec Hélène Munier-Lehmann Didier Mazel Frédérique Le Roux

Genomic data combined with reverse genetic approaches have contributed to the characterization of major virulence factors of Vibrio species; however, these studies have targeted primarily human pathogens. Here, we investigate virulence factors in the oyster pathogen Vibrio splendidus LGP32 and show that toxicity is correlated to the presence of a metalloprotease and its corresponding vsm gene. ...

2011
Jureerut Daduang Temduang Limpaiboon Sakda Daduang

INTRODUCTION The "a distintegrin and metalloprotease" (ADAM) family contributes to regulation of the cell-cell and cell-matrix interaction that are critical determinants of malignancy. It also plays important roles in the degradation of the basement membrane during tumor invasion. To evaluate a distinguishing biomarker for hepatocellular carcinoma from cholangiocarcinoma, a disintegrin and meta...

Journal: :Applied and environmental microbiology 2008
Hiroaki Hasegawa Erin J Lind Markus A Boin Claudia C Häse

Vibrio tubiashii is a recently reemerging pathogen of larval bivalve mollusks, causing both toxigenic and invasive disease. Marine Vibrio spp. produce an array of extracellular products as potential pathogenicity factors. Culture supernatants of V. tubiashii have been shown to be toxic to oyster larvae and were reported to contain a metalloprotease and a cytolysin/hemolysin. However, the struct...

Journal: :The Journal of Cell Biology 1997
Manuela Vecchi Graham Carpenter

The heregulin receptor tyrosine kinase ErbB-4 is constitutively cleaved, in the presence or absence of ligand, by an exofacial proteolytic activity producing a membrane-anchored cytoplasmic domain fragment of 80 kD. Based on selective sensitivity to inhibitors, the proteolytic activity is identified as that of a metalloprotease. The 80-kD product is tyrosine phosphorylated and retains tyrosine ...

2016
Irene Zornetta Domenico Azarnia Tehran Giorgio Arrigoni Fabrizio Anniballi Luca Bano Oneda Leka Giuseppe Zanotti Thomas Binz Cesare Montecucco

The genome of Weissella oryzae SG25T was recently sequenced and a botulinum neurotoxin (BoNT) like gene was identified by bioinformatics methods. The typical three-domains organization of BoNTs with a N-terminal metalloprotease domain, a translocation and a cell binding domains could be identified. The BoNT family of neurotoxins is rapidly growing, but this was the first indication of the possi...

Journal: :FEMS Immunology & Medical Microbiology 2006

Journal: :The Journal of Cell Biology 2002
Yibing Yan Kyoko Shirakabe Zena Werb

Communication between different signaling pathways enables cells to coordinate the responses to diverse environmental signals. Activation of the transmembrane growth factor precursors plays a critical role in this communication and often involves metalloprotease-mediated proteolysis. Stimulation of G protein-coupled receptors (GPCR) transactivates the EGF receptors (EGFRs), which occurs via a m...

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