objective(s): the object of the study is to examine the effects of δ9-tetrahydrocannabinol (thc) against oxidative stress in the blood and excretion of thc metabolites in urine of type 2 diabetic rats. materials and methods: the control (n=8), thc control (n=6), diabetes (n=8) and diabetes + thc (n=7) groups were created. type 2 diabetes was induced by nicotinamide (na, 85 mg/kg) + streptozotoc...

in the past decade, a global demand for products from organic agriculture has increased rapidly. milk quality is of major interest for all parties. therefore, the objective of this study was to compare cow performance and product quality in conventional and organic system. twenty holstein dairy cows were allotted to one of 2 diet groups, which including: a conventional diet (con), and an organi...

this experiment was conducted to evaluate the effects of different levels of portulaca oleracea (po),medicinal plant, on performance, egg traits, blood biochemical and immunity parameters of laying hens. one hundred eighty hi-line (w-36 strain) mature laying hens 65 up to 76 weeks of age were allotted in a completely randomized design consisting of 5 treatments and 3 replicates (12 birds per re...

common carp, cyprinus carpio (l.) were blood-sampled after 0, 2, 6, 12, 24, 48 and 72 h fasting to find serum baseline levels. there was a significant difference in serum glucose, lactate, triglyceride and total protein but not cholesterol, albumin and calcium levels among the treatments. glucose levels increased with fasting tine and reached to a peak after 6 h. then, the glucose level decreas...

A rapid, sensitive and reproducible HPLC method was developed and validatedfor the analysis of amifostine (AMF) and/or its metabolite, WR-1065 inhuman plasma. The method involves the alkylation of free sulfydryl group with iodoacetic acid followed by derivatization of the drug and its metabolite witho-phthaldialdehyde (OPA) andUVdetection at 340 nm. The derivatized AMF and WR-1065 were eluted i...

Imatinib is an orally administered tyrosine kinase inhibitor which inhibits the Bcr-Abl protein-tyrosine kinase with high selectivity. Imatinib is rapidly absorbed from the gut, after oral intake and has an almost absolute bioavailability of 98%. The metabolism of imatinib is mediated by the cytochrome P450 (CYP) isoenzymes in the liver and gut wall. CGP74588 is a major active metabolite of ima...

A bioequivalence study of two verapamil formulations (generic verapamil tablets and Isoptin® tablets) was performed by comparing pharmacokinetic parameters of the parent drug and its major metabolite, norverapamil following a single dose administration of 80 mg verapamil hydrochloride in 22 healthy volunteers according to a randomized, two-period, crossover-design study. Moreover, the feasibili...

A bioequivalence study of two verapamil formulations (generic verapamil tablets and Isoptin® tablets) was performed by comparing pharmacokinetic parameters of the parent drug and its major metabolite, norverapamil following a single dose administration of 80 mg verapamil hydrochloride in 22 healthy volunteers according to a randomized, two-period, crossover-design study. Moreover, the feasibili...